Dkk-1 Antibody [Allophycocyanin]

• Reactivity: Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Allophycocyanin

Dkk-1 Antibody [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant rat Dkk-1 (R&D Systems, Catalog # 4010-DK)
  Ser23-His270
  Accession # NP_001099820
• Specificity: Detects rat Dkk-1 in direct ELISAs and Western blots. In these formats, approximately 40% cross-reactivity with recombinant mouse Dkk-1 is observed and approximately 20% cross-reactivity with recombinant human Dkk-1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: DKK1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for Dkk-1 Antibody [Allophycocyanin]

• dickkopf (Xenopus laevis) homolog 1
• dickkopf homolog 1 (Xenopus laevis)
• dickkopf related protein-1
• Dickkopf-1
• dickkopf-related protein 1
• Dkk1
• Dkk-1
• hDkk-1
• SKdickkopf-1 like

Background

DKK1 is a secreted factor that has been linked to the function of osteoblasts. Elevated DKK1 levels in bone marrow plasma and peripheral blood from patients with multiple myeloma correlated with the gene-expression patterns of DKK1 and were associated with the presence of focal bone lesions. The production of DKK1, an inhibitor of osteoblast differentiation, by myeloma cells is associated with the presence of lytic bone lesions in patients with multiple myeloma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DKK1