Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, approx. pH 7.2.
0.05% Sodium Azide
Immunogen affinity purified
Western blot (WB) analysis of Dio-1 (S186) pAb in extracts from 293 cells. Immunohistochemistry (IHC) analyzes of Dio-1 (S186) pAb in paraffin-embedded human colon carcinoma tissue. Flow data from customer review. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read 1 Review rated 4 using NBP1-19706 in the following application:
Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkappaB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.