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Apoptosis is an important mechanism for discarding damaged, aging or unwanted cells from a particular cellular system. Studies have shown that the 1225-residue Death Associated Transcription Factor 1 (DATF1, also known as death inducer-obliterator 1) is upregulated by apoptotic signal proteins. These same studies have demonstrated that DATF1 is a putative transcription factor that is weakly pro-apoptotic when overexpressed in mice.