DHX58 Antibody

Product Discontinued

DHX58 Antibody Summary

• Immunogen: Synthetic peptide of LGP2 of human origin (Cterminal): IQAKKWSRVPFSV
• Specificity: This recognizes Mouse and Human LGP2
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DHX58
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1-5 ug/ml

Reactivity Notes

This antibody is reactive against Human and Mouse. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and protein stabilizer
• Preservative: 0.05% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for DHX58 Antibody

• D11lgp2e
• D11LGP2probable ATP-dependent RNA helicase DHX58
• DEXH (Asp-Glu-X-His) box polypeptide 58
• EC 3.6.4.13
• LGP2ortholog of mouse D11lgp2
• Probable ATP-dependent helicase LGP2
• Protein D11Lgp2 homolog
• RIG-I-like receptor LGP2
• RLR
• RNA helicase LGP2

Background

**Huge discount for last item in stock** This item has a low concentration and is in the process of being reformulated to have a higher concentration. The last vial of this antibody is available at a large discount but may only be a single use vial. ECL for western blot is recomended to give extra sensitivity. Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DHX58
• Entrez:
  • 79132(Human)
  • 80861(Mouse)