Desmoplakin Antibody (824038) [Alexa Fluor® 647]

• Applications: WB
• Clone: 824038
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Desmoplakin Antibody (824038) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human Desmoplakin
  Asn1796-Val2046
  Accession # P15924
• Specificity: Detects human Desmoplakin in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

DSP (desmoplakin) is the major high molecular weight protein of desmosomes, the most common type of intercellular junction in vertebrate epithelial cells.  DSP is involved in the organization of the desmosomal cadherin-plakoglobin complex, as well as in the anchoring of intermediate filaments to desmosomes.  These functions are thought to impart tensile strength and integrity to epithelial and vascular tissues.  Mutations in DSP result in several clinical phenotypes, ranging from mild skin conditions, to severe skin blistering with subsequent dehydration, to lethal heart defects.  Two major desmoplakin isoforms, DSPI and DSPII, are encoded by alternative mRNA transcripts differentially spliced from the same gene.  Human DSPI is 2,871 amino acids (aa) in length, while DSPII lacks part of a
central alpha-helical rod domain, and is 599 aa shorter.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.