Desmoglein-1 Antibody

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-84567] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-84567] - Analysis in human skin and skeletal muscle tissues. Corresponding DSG1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-84567] - Staining of human skin shows moderate to strong membranous positivity in epidermal cells.

Immunohistochemistry-Paraffin: Desmoglein-1 Antibody [NBP1-84567] - Staining of human esophagus shows moderate to strong membranous positivity in squamous epithelial cells.

Product Discontinued

Desmoglein-1 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: SLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGT
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DSG1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Desmoglein-1 Antibody

• Cadherin family member 4
• CDHF4
• CDHF4PPKS1
• desmoglein 1
• Desmoglein1
• Desmoglein-1
• Desmosomal glycoprotein 1
• DG1
• DGI
• DSG
• DSG1
• Pemphigus foliaceus antigen
• SPPK1

Background

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. Desmoglein 1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Desmoglein-1 Antibody (NBP1-84567)(1)

Publication using NBP1-84567

• Medgyesi B, Dajnoki Z, et al. Rosacea Is Characterized by a Profoundly Diminished Skin Barrier. J Invest Dermatol 2020-10-01 [PMID: 32199994] (IHC-P, Human)

FAQs for Desmoglein-1 Antibody (NBP1-84567). (Showing 1 - 1 of 1 FAQ).

1. I need a specific antibody that targets the N-terminal part (extracellular) of Desmoglein 1 protein (Dsg1). Do you offer any such antibody?
   • I believe our product NBP1-84567 meets your requirements. The immunogenic peptide sequence is shown on the web page / datasheet for this antibody. UniProt tells me that the extracellular domain of Desmoglein 1 is residues 50-548. The immunogen for this antibody lies within this region (residues 344-478).

Bioinformatics

• Gene Symbol: DSG1