Desmocollin-2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human colon, esophagus, liver and tonsil using Anti-DSC2 antibody NBP1-85711 (A) shows similar protein distribution across tissues to independent antibody NBP1-85710 (B).

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human cerebral cortex shows no positivity in neurons as expected.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human colon shows moderate membranous positivity in glandular cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human tonsil shows strong membranous positivity in squamous epithelial cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human esophagus shows strong membranous positivity in squamous epithelial cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human liver shows weak membranous positivity in hepatocytes.

Immunohistochemistry analysis in human esophagus and cerebral cortex tissues using HPA011911 antibody. Corresponding DSC2 RNA-seq data are presented for the same tissues.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Desmocollin-2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Desmocollin-2 Antibody - BSA Free (NBP1-85711) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: IGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNS
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DSC2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Desmocollin-2 Protein (NBP1-85711PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Desmocollin-2 Antibody - BSA Free

• ARVD11
• Cadherin family member 2
• CDHF2
• CDHF2DGII/III
• desmocollin 2
• Desmocollin2
• Desmocollin-2
• Desmocollin-3
• Desmosomal glycoprotein II
• desmosomal glycoprotein II/III
• Desmosomal glycoprotein III
• DG2
• DSC2
• DSC3DKFZp686I11137

Background

Desmocollin 2 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Desmocollin-2 Antibody (NBP1-85711). (Showing 1 - 1 of 1 FAQ).

1. Does this antibody cross react with descmocollin-2 and descmocollin-3?
   • According to UniProt, the gene DSC2 has two isoforms associated with it. Isoform 2A (canonical sequence) is also referred to as Desmocollin-2, and Isoform 2B is also referred to as Desmocollin-3. This is why we have it listed as an alternate name. The immunogen of the antibody is 100% homologous in both isoforms, so this antibody should recognize both Isoform 2A and 2B.

Bioinformatics

• Gene Symbol: DSC2