Desmocollin-2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human colon shows moderate membranous positivity in glandular cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining in human esophagus and cerebral cortex tissues.. Corresponding DSC2 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human esophagus shows strong membranous positivity in squamous epithelial cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human tonsil shows strong membranous positivity in squamous epithelial cells.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human liver shows weak membranous positivity in hepatocytes.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human cerebral cortex shows no positivity in neurons as expected.

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85710] - Staining of human colon, esophagus, liver and tonsil using Anti-DSC2 antibody NBP1-85710 (A) shows similar protein distribution across tissues to independent antibody NBP1-85711 (B).

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Desmocollin-2 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit Desmocollin-2 Antibody - BSA Free (NBP1-85710) is a polyclonal antibody validated for use in IHC. Anti-Desmocollin-2 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: KTVIICKPTMSSAEIVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQNDPPFGSYVVPITVRDRLGMSSVTSLDVTLCDCITENDCTHRVDPRIGGGGVQLGKW
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DSC2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Desmocollin-2 Protein (NBP1-85710PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Desmocollin-2 Antibody - BSA Free

• ARVD11
• Cadherin family member 2
• CDHF2
• CDHF2DGII/III
• desmocollin 2
• Desmocollin2
• Desmocollin-2
• Desmocollin-3
• Desmosomal glycoprotein II
• desmosomal glycoprotein II/III
• Desmosomal glycoprotein III
• DG2
• DSC2
• DSC3DKFZp686I11137

Background

Desmocollin 2 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Desmocollin-2 Antibody (NBP1-85710)(1)

Publication using NBP1-85710

• Gehmlich K, Syrris P, Peskett E et al. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res 2011-04-01 [PMID: 21062920]

Bioinformatics

• Gene Symbol: DSC2