DcR3/TNFRSF6B Antibody (229817) [Janelia Fluor® 549]

• Reactivity: Hu
• Applications: WB, ELISA, ELISA(Cap), ELISA(Det)
• Clone: 229817
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 549

DcR3/TNFRSF6B Antibody (229817) [Janelia Fluor® 549] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human DcR3/TNFRSF6B
  Val24-His300
  Accession # O95407
• Specificity: Detects human DcR3/TNFRSF6B in ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) OPG, recombinant mouse (rm) OX40, rhRANK, rhRELT, rhTAJ, rhTNF RI, rhTNF RII, rhTRADD, rhTWEAK R, rhTRAIL RI, rhTRAIL R2, rhTRAIL R3, or rhTRAIL R4 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNFRSF6B
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for DcR3/TNFRSF6B Antibody (229817) [Janelia Fluor® 549]

• DcR3
• DCR3Decoy receptor for Fas ligand
• Decoy receptor 3
• M68
• M68DJ583P15.1.1
• TNFRSF6B
• TR6
• TR6DcR3
• tumor necrosis factor receptor superfamily member 6B
• tumor necrosis factor receptor superfamily, member 6b, decoy

Background

DcR3 belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF6B