DC-STAMP/TM7SF4 Antibody (788524) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 788524
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

DC-STAMP/TM7SF4 Antibody (788524) [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects human DC-STAMP in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse DC-STAMP is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for DC-STAMP/TM7SF4 Antibody (788524) [Alexa Fluor™ Plus 594]

• DCSTAMP
• DC-STAMP
• dendritic cell-specific transmembrane protein
• FIND
• IL-4-induced Protein
• TM7SF4
• transmembrane 7 superfamily member 4

Background

DC-STAMP, also known as TM7SF4, is an approximately 50 kDa glycoprotein with seven transmembrane segments. It is expressed on the surface of dendritic cells and monocytes as well as on osteoclasts and their progenitors. DC-STAMP binds CTGF/CCN2 and cooperates with TRANCE/RANK L for inducing osteoclast differentiation and fusion into multinucleated cells. It contains a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and associates with FC gamma RIII/CD16. Within aa 314-376, human DC-STAMP shares approximately 75% aa sequence identity with mouse and rat DC-STAMP.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.