DAP12 Antibody

Images

 
Immunohistochemistry-Paraffin: DAP12 Antibody [NBP1-52376] - Analysis of anti-TYROBP / DAP12 antibody with human spleen at concentration 3 ug/ml.
Immunohistochemistry-Paraffin: DAP12 Antibody [NBP1-52376] - Analysis of anti-TYROBP / DAP12 antibody with human uterus at concentration 3 ug/ml.

Product Details

Summary
Reactivity Hu, Bt, Ca, Eq, Mk, Pm, Rb, ShSpecies Glossary
Applications ELISA, IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

DAP12 Antibody Summary

Immunogen
Synthetic peptide C-KQRITETESPYQE from an internal region of human TYROBP / DAP12 (NP_003323.1; NP_937758.1).
Specificity
Human TYROBP / DAP12. This antibody is expected to recognize both reported isoforms (NP_003323.1; NP_937758.1)
Predicted Species
Rabbit (92%), Sheep (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TYROBP
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • ELISA 1:100 - 1:2000
  • Immunohistochemistry-Paraffin 3-6 ug/ml
Application Notes
IHC: NBP1-52376 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.

Reactivity Notes

Chimpanzee, Gorilla, Gibobn, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (92%), Mouse (85%), Elephant (85%), Zebu (85%), Bovine (85%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DAP12 Antibody

  • DAP12
  • DAP12PLOSL
  • DNAX-activation protein 12
  • KARAP
  • KARAPPLO-SL
  • KAR-associated protein
  • killer activating receptor associated protein
  • Killer-activating receptor-associated protein
  • TYRO protein tyrosine kinase binding protein
  • TYRO protein tyrosine kinase-binding protein
  • TYROBP

Background

The 32kDa dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein (DARPP-32) can either function as a serine/threonine kinase or as a serine/threonine phosphatase depending upon which particular amino acid residue is phosphorylated (1). When phosphorylated by protein kinase A (PKA) at threonine 34, DARPP-32 becomes a potent inhibitor of protein phosphatase-1 (2-3). Alternatively, when phosphorylated at threonine 75 by cyclin-dependent kinase 5(Cdk5), DARPP-32 is converted into an inhibitor of PKA (1). DARPP-32 and truncated DARPP (t-DARPP) are overexpressed in gastric cancers (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TYROBP
Entrez
Uniprot