Cytokeratin 16 Antibody

Images

 
Western Blot: Cytokeratin 16 Antibody [NBP1-32709] - Sample (30 ug of whole cell lysate)A: HeLa10% SDS PAGE, antibody diluted at 1:1000.
Immunohistochemistry-Paraffin: Cytokeratin 16 Antibody [NBP1-32709] - Paraffin-embedded H441 xenograft, using antibody at 1:100 dilution.

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.77 mg/ml

Order Details

Cytokeratin 16 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human Cytokeratin 16. The exact sequence is proprietary.
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KRT16
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Chimpanzee (100%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.77 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Cytokeratin 16 Antibody

  • CK16
  • CK-16
  • cytokeratin 16
  • cytokeratin-16
  • FNEPPK
  • focal non-epidermolytic palmoplantar keratoderma
  • K16
  • K1CP
  • keratin 16
  • keratin, type I cytoskeletal 16
  • keratin-16
  • KRT16A
  • NEPPK

Background

Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. Two cytokeratins, 6 and 16, are expressed when keratincytes are undergoing rapid turnover in various pathological states, wound healing, psoriasis and some carcinomas

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KRT16