Cysteinyl Leukotriene R2/CysLTR2 Antibody

Immunohistochemistry-Paraffin: Cysteinyl Leukotriene R2/CysLTR2 Antibody [NBP1-02650] - Staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Product Discontinued

Cysteinyl Leukotriene R2/CysLTR2 Antibody Summary

• Immunogen: Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human CYSLTR2 / CYSLT2.
• Specificity: Human CYSLTR2 / CYSLT2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SNX11 (55%).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYSLTR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (95%), Marmoset (80%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cysteinyl Leukotriene R2/CysLTR2 Antibody

• CysLT(2)
• CysLT2
• CYSLT2KPG_011
• CYSLT2RHG57
• CysLTR2
• cysteinyl leukotriene CysLT2 receptor
• Cysteinyl Leukotriene R2
• cysteinyl leukotriene receptor 2
• Cysteinyl LeukotrieneR2
• G protein-coupled receptor
• G-protein coupled receptor GPCR21
• G-protein coupled receptor HG57
• HG57
• hGPCR21
• HPN321
• KPG_011

Background

Cysteinyl leukotriene receptor 2 (CysLT2) is a Chemoattractant Receptor that binds neutrophil chemoattractants such as cysteinyl leukotrienes. These ligands have potent proinflammatory activity and are implicated in many features of asthma including edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Activation of cysteinyl leukotriene receptor 2 induces cell contraction and/or relaxation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYSLTR2
• Entrez:
  • 57105(Human)
• Uniprot:
  • Q9NS75(Human)