Cystathionase Antibody (4E1-1B7)

Images

 
Western Blot: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - CTH monoclonal antibody (M01), clone 4E1-1B7. Analysis of CTH expression in human liver.
Immunohistochemistry-Paraffin: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - Immunoperoxidase of monoclonal antibody to CTH ( Cat # H00001491-M01 ) on formalin-fixed paraffin-embedded human colon. [antibody ...read more
Western Blot: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - CTH expression in K-562 ( Cat # L009V1 ).
Western Blot: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - CTH monoclonal antibody (M01), clone 4E1-1B7. Analysis of CTH expression in Hela S3 NE.
Western Blot: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - Analysis of CTH expression in transfected 293T cell line by CTH monoclonal antibody (M01), clone 4E1-1B7.Lane 1: CTH transfected lysate (Predicted MW: ...read more
ELISA: Cystathionase Antibody (4E1-1B7) [H00001491-M01] - Detection limit for recombinant GST tagged CTH is approximately 1ng/ml as a capture antibody.

Product Details

Summary
Reactivity Hu, GPSpecies Glossary
Applications WB, ELISA, IHC-P
Clone
4E1-1B7
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Cystathionase Antibody (4E1-1B7) Summary

Immunogen
CTH (AAH15807, 1 a.a. - 405 a.a.) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGRSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
Localization
Cytoplasmic
Specificity
CTH - cystathionase (cystathionine gamma-lyase)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CTH
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunohistochemistry-Paraffin
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
Publications
Read Publications using
H00001491-M01 in the following applications:

  • 2 publications
  • IHC
    1 publication
  • WB
    4 publications

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

Quality control test: Antibody Reactive Against Recombinant Protein.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cystathionase Antibody (4E1-1B7)

  • cystathionase (cystathionine gamma-lyase)
  • cystathionine gamma-lyase
  • cysteine desulfhydrase
  • EC 4.4.1
  • EC 4.4.1.1
  • gamma-cystathionase
  • homoserine deaminase
  • homoserine dehydratase
  • MGC9471

Background

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Cystathionase Antibody (H00001491-M01)(27)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: ICC/IF, IHC, WB.


Filter By Application
ICC/IF
(2)
IHC
(1)
WB
(4)
All Applications
Filter By Species
Human
(2)
Mouse
(2)
Rat
(1)
All Species
Showing Publications 1 - 10 of 27. Show All 27 Publications.
Publications using H00001491-M01 Applications Species
Yuan YQ, Wang YL, Yuan BS et al. Impaired CBS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson's disease. Brain Behav Immun 2017 Jul 31 [PMID: 28774789]
Mitidieri E, Tramontano T, Gurgone D et al. B3 adrenergic receptor activation relaxes human corpus cavernosum and penile artery through a hydrogen sulfide/cGMP-dependent mechanism. Pharmacol Res 2017 Jul 29 [PMID: 28760490]
Nubbaum BL, McCook O, Hartmann C et al. Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis. Intensive Care Med Exp 2016 Jun [PMID: 27271248]
Li JJ, Li Q, Du HP et al. Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter. Int. 2015 Jun 03 [PMID: 26047341]
Xu Y, Du HP, Li J et al. Statins upregulate cystathionine gamma-lyase transcription and H2S generation via activating Akt signaling in macrophage. Pharmacol Res. 2014 Sep [PMID: 24951966] (Mouse) Mouse
Ida T, Sawa T, Ihara H et al. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl Acad Sci U S A. 2014 Apr 14 [PMID: 24733942]
Badiei A, Rivers-Auty J, Ang AD, Bhatia M. Inhibition of hydrogen sulfide production by gene silencing attenuates inflammatory activity of LPS-activated RAW264.7 cells. Appl Microbiol Biotechnol. 2013 Jul 10 [PMID: 23838794]
Mani S, Li H, Untereiner A et al. Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis. Circulation. 2013 May 23 [PMID: 23704252]
Cindrova-Davies T, Herrera EA, Niu Y et al. Reduced Cystathionine gamma-Lyase and Increased MicroRNA-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies: Hydrogen Sulfide as a Placental Vasodilator. Am J Pathol 2013 Feb 11 [PMID: 23410520] (WB, Human) WB Human
Bucci M, Papapetropoulos A, Vellecco V et al. cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation PLoS One 2012 [PMID: 23285278] (IHC, ICC/IF, WB, Mouse) IHC, ICC/IF, WB Mouse
Show All 27 Publications.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Cystathionase Antibody (H00001491-M01). (Showing 1 - 1 of 1 FAQs).

  1. We found the difference of Species info between Novus and Abnova pages regarding the same antibody H00001491-M01. Because our customer would like use this antibody with samples from mouse and rat, we wonder if this antibody is suitable?
    • Actually, H00001491-M01 has been successfully tested with Mouse and Rat samples by our customers as is evident from published papers. Following research papers may be referred for additional details: Bucci M, Papapetropoulos A, Vellecco V et al. cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation PLoS One 2012 [PMID: 23285278] (IHC, ICC/IF, WB, Mouse) Wallace JL, Dicay M, McKnight W et al. Hydrogen sulfide enhances ulcer healing in rats. FASEB J;21(14):4070-6. 2007 Dec. [PMID: 17634391] (rat)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CTH
Entrez
OMIM
Uniprot