CYP51A1 Antibody

Western Blot: CYP51A1 Antibody [H00001595-A01] - Detection against Immunogen (37.11 KDa) .

Product Discontinued

CYP51A1 Antibody Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: CYP51A1 (NP_000777, 410 a.a. - 509 a.a.) partial recombinant protein with GST tag. SPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
• Specificity: CYP51A1 - cytochrome P450, family 51, subfamily A, polypeptide 1
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: CYP51A1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: The quality control of this antibody is limited to WB on the immunizing protein. It has been used for ELISA.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 24516236). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50 % glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CYP51A1 Antibody

• CP51
• CYP51
• CYP51A1
• CYP51Cytochrome P450LI
• CYPL1
• CYPLI
• Cytochrome P450 51A1
• cytochrome P450, family 51, subfamily A, polypeptide 1
• Cytochrome P45014DM
• Cytochrome P450-14DM
• Cytochrome P450LI
• EC 1.14.13.70
• EC 1.14.14.154
• lanosterol 14-alpha demethylase
• lanosterol 14-alpha-demethylase
• LDM
• LDMCytochrome P45014DM
• P450-14DM
• P450L1,51 (lanosterol 14-alpha-demethylase)
• Sterol 14-alpha demethylase

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CYP51A1 Antibody (H00001595-A01)(3)

Publications using H00001595-A01

• Miao Ji, Haas Joel T, Manthena Praveen et al. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res. 2014-02-10 [PMID: 24516236] (Mouse)
• Wang W, Mutka AL, Zmrzljak UP et al. Amyloid precursor protein alpha- and beta-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2. FASEB J. 2014-02-01 [PMID: 24249638] (Human)
• Watanabe H, Hirai S, Tateno H, Fukui Y. Variation of cholesterol contents in porcine cumulus-oocyte complexes is a key factor in regulation of fertilizing capacity. Theriogenology. 2012-11-23 [PMID: 23273431]

Bioinformatics

• Gene Symbol: CYP51A1
• Entrez:
  • 1595(Human)
• OMIM:
  • 601637(Human)
• Uniprot:
  • NP_000777(Human)