CYP51A1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi’s unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	1595
Alternate Names	CP51 CYP51 CYP51A1 CYP51Cytochrome P450LI CYPL1 CYPLI Cytochrome P450 51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 Cytochrome P45014DM Cytochrome P450-14DM Cytochrome P450LI EC 1.14.13.70 EC 1.14.14.154 lanosterol 14-alpha demethylase lanosterol 14-alpha-demethylase LDM LDMCytochrome P45014DM P450-14DM P450L1,51 (lanosterol 14-alpha-demethylase) Sterol 14-alpha demethylase