CXCL10/IP-10/CRG-2 Antibody (163426) [Alexa Fluor® 350]

• Reactivity: Cr
• Applications: WB, B/N
• Clone: 163426
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

CXCL10/IP-10/CRG-2 Antibody (163426) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant cotton rat CXCL10/IP‑10/CRG‑2
  Ile22-Val94
  Accession # AAL16935
• Specificity: Detects cotton rat CXCL10/IP‑10/CRG‑2 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human CXCL1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 16, recombinant mouse CXCL1, 2, 4, 6, 7, 9, 10, 11, 12, 13, 15 or 16, recombinant rat CX
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Neutralization
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL10/IP-10/CRG-2 Antibody (163426) [Alexa Fluor® 350]

• C7
• chemokine (C-X-C motif) ligand 10
• CRG2
• CRG-2
• CXCL10
• gIP-10
• IFI10
• INP10
• IP-10
• mob-1
• SCYB10

Background

IP-10, also named mob-1 in rat and crg-2 in mouse, is a member of the non-ELR-motif containing CXC chemokine subfamily and has been designated CXCL10. It is induced in various cell types (including keratinocytes, endothelial cells, fibroblasts, smooth muscle cells, monocytes/macrophages, astrocytes, neutrophils, hepatocytes, T cells, epithelial cells and mesothelial cells) in response to stimulation by type I and/or type II interferon as well as by LPS. IP-10 has been shown to chemoattract activated CD4⁺ and CD8⁺ T cells, activated NK cells and smooth muscle cells. It also induces the adhesion of activated T cells to VCAM and ICAM. In addition, IP-10 has been reported to antagonize the angiogenic activity of FGF. IP-10 binds to and activates CXCR3, the chemokine receptor that is shared by MIG/CXCL9 and I-TAC/CXCL11, two additional non-ELR CXC chemokines that are induced by interferon. Cotton rat IP-10 cDNA encodes a 94 amino acid (aa) residue precursor protein with a putative 21 aa signal peptide and a 73 aa mature protein with one potential N-linked glycosylation site. Mature cotton rat IP-10 shares 66%, 64%, and 66% aa sequence identity with rat, mouse and human IP10, respectively (1‑7).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.