CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]


Recombinant Mouse CXCL1/GRO alpha /KC/CINC‑1 aa 20‑96 (Catalog # 453-KC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that more

Product Details

Reactivity MuSpecies Glossary
Applications WB, B/N, ELISA(Cap)

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CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated] Summary

E. coli-derived recombinant mouse CXCL1/GRO alpha /KC/CINC-1
Accession # P12850
Detects mouse CXCL1/GRO alpha /KC/CINC-1 in direct ELISAs and Western blots. Shows 100% cross‑reactivity with recombinant human (rh) CXCL2, less than 40% cross‑reactivity with recombinant rat (rr) CINC-1, and no cross‑reactivity with rrCINC-3, rhCXCL3, rhCXCL5, rhCXCL6, or recombinant mouse CXCL6.
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • Neutralization 0.05-0.25 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Detection: Mouse CXCL1/GROalpha /KC/CINC-1 Biotinylated Antibody (Catalog number BAF453)
Standard: Recombinant Mouse CXCL1/GROalpha /KC/CINC-1 aa 20-96 (Catalog number 453-KC)
Read Publications using
MAB453 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]

  • CINC1
  • CINC-1
  • CXCL1
  • GRO alpha
  • KC
  • MGSA-alpha


CXCL1, also known as KC and GRO alpha, is a CXC family chemokine that is expressed in fibroblasts, macrophages, and endothelial cells and interacts with CXCR2. CXCL1 is a potent neutrophil attractant and activator. It also promotes angiogenesis by inducing VEGF production by neutrophils. N-terminally truncated CXCL1 demonstrates increased potency in CXCR2 signaling. Mature mouse CXCL1 shares 96% and 64% aa sequence identity with rat and human CXCL1, respectively.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)(40)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 9 applications: Bioassay, ELISA Capture, ELISA Development, IHC Paraffin-embedded, IP, In vivo, Luminex Assay Development, Neut, WB.

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Showing Publications 1 - 10 of 40. Show All 40 Publications.
Publications using MAB453 Applications Species
G Andonegui, EL Zelinski, CL Schubert, D Knight, LA Craig, BW Winston, SC Spanswick, B Petri, CN Jenne, JC Sutherland, R Nguyen, N Jayawarden, MM Kelly, CJ Doig, RJ Sutherland, P Kubes Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment JCI Insight, 2018;3(9):. 2018 [PMID: 29720578] (In vivo,, Mouse) In vivo Mouse
EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017;0(0):. 2017 [PMID: 29282312] (Neut,, Mouse) Neut Mouse
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017;42(5):1961-1972. 2017 [PMID: 28793286] (ELISA Capture,, Mouse) ELISA Capture Mouse
Elena Farmaki Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived CCL3 Cancer Lett, 2016;0(0):. 2016 [PMID: 28041977] (Neut,, Mouse) Neut Mouse
Clara Jana-Lui Busch Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice Hepatology, 2016;0(0):. 2016 [PMID: 27981604] (ELISA Capture,, Mouse) ELISA Capture Mouse
Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27528685] (In vivo,, Mouse) In vivo Mouse
Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype PLoS ONE, 2016;11(8):e0159986. 2016 [PMID: 27525971] (Bioassay,, Mouse) Bioassay Mouse
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity Sci Rep, 2016;6(0):29994. 2016 [PMID: 27444332] (Neut,, Mouse) Neut Mouse
L Seifert, G Werba, S Tiwari, NN Giao Ly, S Alothman, D Alqunaibit, A Avanzi, R Barilla, D Daley, SH Greco, A Torres-Her, M Pergamo, A Ochi, CP Zambirinis, M Pansari, M Rendon, D Tippens, M Hundeyin, VR Mani, C Hajdu, D Engle, G Miller The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression Nature, 2016;532(7598):245-9. 2016 [PMID: 27049944] (In vivo,, Mouse) In vivo Mouse
Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, Walker S, Gregory L, Lloyd C Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity, 0;43(5):945-58. 0 [PMID: 26588780] (ELISA Capture,, Mouse) ELISA Capture Mouse
Show All 40 Publications.

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Gene Symbol Cxcl1