CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]

Images

 
Recombinant Mouse CXCL1/GRO alpha /KC/CINC‑1 aa 20‑96 (Catalog # 453-KC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, B/N, ELISA(Cap)
Clone
48415
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

View Available Formulations
Catalog# & Formulation Size Price

CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant mouse CXCL1/GRO alpha /KC/CINC-1
Arg20-Lys96
Accession # P12850
Specificity
Detects mouse CXCL1/GRO alpha /KC/CINC-1 in direct ELISAs and Western blots. Shows 100% cross‑reactivity with recombinant human (rh) CXCL2, less than 40% cross‑reactivity with recombinant rat (rr) CINC-1, and no cross‑reactivity with rrCINC-3, rhCXCL3, rhCXCL5, rhCXCL6, or recombinant mouse CXCL6.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
Cxcl1
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • Neutralization 0.05-0.25 ug/mL
  • ELISA Standard (Matched Pair)
Application Notes
ELISA Detection: Mouse CXCL1/GROalpha /KC/CINC-1 Biotinylated Antibody (Catalog number BAF453)
Standard: Recombinant Mouse CXCL1/GROalpha /KC/CINC-1 aa 20-96 (Catalog number 453-KC)
Publications
Read Publications using
MAB453 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]

  • CINC1
  • CINC-1
  • CXCL1
  • GRO alpha
  • KC
  • MGSA-alpha

Background

CXCL1, also known as KC and GRO alpha, is a CXC family chemokine that is expressed in fibroblasts, macrophages, and endothelial cells and interacts with CXCR2. CXCL1 is a potent neutrophil attractant and activator. It also promotes angiogenesis by inducing VEGF production by neutrophils. N-terminally truncated CXCL1 demonstrates increased potency in CXCR2 signaling. Mature mouse CXCL1 shares 96% and 64% aa sequence identity with rat and human CXCL1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB208
Species: Hu
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
NB120-14817
Species: Hu, Rt
Applications: WB, ICC/IF, IHC, S-ELISA
MAB331
Species: Hu
Applications: Flow, IHC, CyTOF-ready, Neut
MAB393
Species: Hu
Applications: WB, Simple Western, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
AF3667
Species: Hu, Mu
Applications: WB, Simple Western, IHC, ICC
NB100-56583
Species: Hu
Applications: WB, Flow, IHC-P
MAB330
Species: Hu
Applications: Flow, IHC, CyTOF-reported, Neut

Publications for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)(40)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 9 applications: Bioassay, ELISA Capture, ELISA Development, IHC Paraffin-embedded, IP, In vivo, Luminex Assay Development, Neut, WB.


Filter By Application
Bioassay
(1)
ELISA Capture
(5)
ELISA Development
(15)
IHC Paraffin-embedded
(1)
IP
(1)
In vivo
(11)
Luminex Assay Development
(1)
Neut
(4)
WB
(1)
All Applications
Filter By Species
Mouse
(40)
All Species
Showing Publications 1 - 10 of 40. Show All 40 Publications.
Publications using MAB453 Applications Species
G Andonegui, EL Zelinski, CL Schubert, D Knight, LA Craig, BW Winston, SC Spanswick, B Petri, CN Jenne, JC Sutherland, R Nguyen, N Jayawarden, MM Kelly, CJ Doig, RJ Sutherland, P Kubes Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment JCI Insight, 2018;3(9):. 2018 [PMID: 29720578] (In vivo,, Mouse) In vivo Mouse
EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017;0(0):. 2017 [PMID: 29282312] (Neut,, Mouse) Neut Mouse
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017;42(5):1961-1972. 2017 [PMID: 28793286] (ELISA Capture,, Mouse) ELISA Capture Mouse
Elena Farmaki Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived CCL3 Cancer Lett, 2016;0(0):. 2016 [PMID: 28041977] (Neut,, Mouse) Neut Mouse
Clara Jana-Lui Busch Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice Hepatology, 2016;0(0):. 2016 [PMID: 27981604] (ELISA Capture,, Mouse) ELISA Capture Mouse
Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27528685] (In vivo,, Mouse) In vivo Mouse
Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype PLoS ONE, 2016;11(8):e0159986. 2016 [PMID: 27525971] (Bioassay,, Mouse) Bioassay Mouse
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity Sci Rep, 2016;6(0):29994. 2016 [PMID: 27444332] (Neut,, Mouse) Neut Mouse
L Seifert, G Werba, S Tiwari, NN Giao Ly, S Alothman, D Alqunaibit, A Avanzi, R Barilla, D Daley, SH Greco, A Torres-Her, M Pergamo, A Ochi, CP Zambirinis, M Pansari, M Rendon, D Tippens, M Hundeyin, VR Mani, C Hajdu, D Engle, G Miller The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression Nature, 2016;532(7598):245-9. 2016 [PMID: 27049944] (In vivo,, Mouse) In vivo Mouse
Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, Walker S, Gregory L, Lloyd C Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity, 0;43(5):945-58. 0 [PMID: 26588780] (ELISA Capture,, Mouse) ELISA Capture Mouse
Show All 40 Publications.

Reviews for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453) (0)

There are no reviews for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)

Discover related pathways, diseases and genes to CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)

Discover more about diseases related to CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453).
 

Pathways for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)

View related products by pathway.

PTMs for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)

Learn more about PTMs related to CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453).

Blogs on CXCL1/GRO alpha/KC/CINC-1

There are no specific blogs for CXCL1/GRO alpha/KC/CINC-1, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated] and receive a gift card or discount.

Bioinformatics

Gene Symbol Cxcl1
Entrez
Uniprot