CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]

Recombinant Mouse CXCL1/GRO alpha /KC/CINC‑1 aa 20‑96 (Catalog # 453-KC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Mouse CXCL1/GRO alpha /KC/CINC‑1 aa 20‑96 (30 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse CXCL1/GRO alpha /KC/CINC‑1 Monoclonal Antibody (Catalog # MAB453). The ND50 is typically0.05‑0.25 µg/mL.

• Reactivity: Mu
• Applications: WB, B/N, ELISA(Cap)
• Clone: 48415
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Unconjugated

CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant mouse CXCL1/GRO alpha /KC/CINC-1
  Arg20-Lys96
  Accession # P12850
• Specificity: Detects mouse CXCL1/GRO alpha /KC/CINC-1 in direct ELISAs and Western blots. Shows 100% cross‑reactivity with recombinant human (rh) CXCL2, less than 40% cross‑reactivity with recombinant rat (rr) CINC-1, and no cross‑reactivity with rrCINC-3, rhCXCL3, rhCXCL5, rhCXCL6, or recombinant mouse CXCL6.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: Cxcl1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.1-0.4 ug/mL
  • ELISA Standard (Matched Pair)
  • Neutralization 0.05-0.25 ug/mL
  • Western Blot 1 ug/mL
• Application Notes: ELISA Detection: Mouse CXCL1/GROalpha /KC/CINC-1 Biotinylated Antibody (Catalog number BAF453)
  Standard: Recombinant Mouse CXCL1/GROalpha /KC/CINC-1 aa 20-96 (Catalog number 453-KC)

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL1/GRO alpha/KC/CINC-1 Antibody (48415) [Unconjugated]

• CINC1
• CINC-1
• CXCL1
• FSP
• GRO alpha
• GRO1
• GROa
• KC
• MGSA
• MGSA-a
• MGSA-alpha
• NAP-3
• SCYB1

Background

CXCL1, also known as KC and GRO alpha, is a CXC family chemokine that is expressed in fibroblasts, macrophages, and endothelial cells and interacts with CXCR2. CXCL1 is a potent neutrophil attractant and activator. It also promotes angiogenesis by inducing VEGF production by neutrophils. N-terminally truncated CXCL1 demonstrates increased potency in CXCR2 signaling. Mature mouse CXCL1 shares 96% and 64% aa sequence identity with rat and human CXCL1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB453)(73)

Publications using MAB453

• Dong, A;Wei, G;Liang, Z;Di, Y;Tang, Y;Ling, Y;Li, S;Chen, Y;Zhou, Y;Wang, X;Peng, Z; Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment Nature communications 2025-07-02 [PMID: 40603284] (Neutralization, Transgenic Mouse)
• Lee, J;Cho, W;Yu, JW;Hyun, YM; NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain Journal of neuroinflammation 2025-05-24 [PMID: 40413505] (Bioassay, Mouse)
• Kim, H;Shin, CY;Park, CH;Lee, DH;Lee, SH;Chung, JH; The pivotal role of osteopontin in UV-induced skin inflammation in a mouse model Open biology 2024-11-01 [PMID: 39533922] (ELISA Capture, Mouse)
• Di, Y;Wang, Z;Xiao, J;Zhang, X;Ye, L;Wen, X;Qin, J;Lu, L;Wang, X;He, W; ACSL6-activated IL-18R1-NF-?B promotes IL-18-mediated tumor immune evasion and tumor progression Science advances 2024-09-20 [PMID: 39292786] (In vivo assay, Mouse)
• Bénard, A;Mittelstädt, A;Klösch, B;Glanz, K;Müller, J;Schoen, J;Nüse, B;Brunner, M;Naschberger, E;Stürzl, M;Mattner, J;Muñoz, LE;Sohn, K;Grützmann, R;Weber, GF; IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils Cell reports 2023-06-08 [PMID: 37300834] (In Vivo, Mouse)
• Konghuai Wang, Lu Zhou, Hanqing Mao, Jiayi Liu, Zhi Chen, Lu Zhang Intercellular mitochondrial transfer alleviates pyroptosis in dental pulp damage Cell Proliferation 4/21/2023 [PMID: 37086012]
• PS Coburn, AC Parrott, FC Miller, AL LaGrow, MH Mursalin, MC Callegan The Role of C-X-C Chemokines in Staphylococcus aureus Endophthalmitis Investigative Ophthalmology & Visual Science, 2023-03-01;64(3):10. 2023-03-01 [PMID: 36867134] (In Vivo, Mouse)
• Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton bioRxiv 2023-05-07 [PMID: 36711531] (CyTof, Mouse)
• Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton bioRxiv 5/7/2023 [PMID: 36711531]
• YS Hwang, HJ Cho, ES Park, J Lim, HR Yoon, JT Kim, SR Yoon, H Jung, YK Choe, YH Kim, CH Lee, YT Kwon, BY Kim, HG Lee KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages Cells, 2022-12-16;11(24):. 2022-12-16 [PMID: 36552865] (Neutralization, Mouse)
• Y Yu, RR Wang, NJ Miao, JJ Tang, YW Zhang, XR Lu, PY Yan, J Wang, XM Jia PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow Nature Communications, 2022-11-11;13(1):6857. 2022-11-11 [PMID: 36369287] (IHC, Mouse)
• J Yang, L Jin, HS Kim, F Tian, Z Yi, K Bedi, M Ljungman, M Pasca di M, H Crawford, J Shi KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer Cancer Research, 2022-11-15;0(0):OF1-OF14. 2022-11-15 [PMID: 36306422] (Neutralization, Human, Mouse)
• V Grubiši?, V Bali, DE Fried, HK Eltzschig, SC Robson, MS Mazei-Robi, BD Gulbransen Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis Mucosal Immunology, 2022-07-22;0(0):. 2022-07-22 [PMID: 35869148] (Neutralization, Mouse)
• D Kang, J Lee, J Jung, BA Carlson, MJ Chang, CB Chang, SB Kang, BC Lee, VN Gladyshev, DL Hatfield, BJ Lee, JH Kim Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis Nature Communications, 2022-02-09;13(1):779. 2022-02-09 [PMID: 35140209] (IHC, Human)
• Saborni Chakraborty, Joseph C. Gonzalez, Benjamin L. Sievers, Vamsee Mallajosyula, Srijoni Chakraborty, Megha Dubey et al. Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity Science Translational Medicine 3/9/2022 [PMID: 35040666]
• Li-Wen Lo, Chia-Wei Chang, Ming-Feng Chiang, I-Ying Lin, Kuo-I Lin Marginal Zone B Cells Assist With Neutrophil Accumulation to Fight Against Systemic Staphylococcus aureus Infection Frontiers in Immunology 5/10/2021 [PMID: 34040603]
• Anna Barkaway, Loïc Rolas, Régis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods et al. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage Immunity 7/13/2021 [PMID: 34033752]
• ZZ Liu, YJ Yang, FH Zhou, K Ma, XQ Lin, SQ Yan, Y Gao, W Chen GSDMD contributes to host defence against Staphylococcus aureus skin infection by suppressing the Cxcl1-Cxcr2 axis Veterinary research, 2021-05-19;52(1):71. 2021-05-19 [PMID: 34011393] (In Vivo, Mouse)
• Qianfei Zhang, Chi Ma, Yi Duan, Bernd Heinrich, Umberto Rosato, Laurence P. Diggs et al. Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma Cancer Discovery 5/1/2021 [PMID: 33323397]
• Cristabelle De Souza, Jill A. Madden, Dennis Minn, Vigneshwari Easwar Kumar, Dennis J. Montoya, Roshni Nambiar et al. The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression International Journal of Molecular Sciences 10/28/2020 [PMID: 33126568]
• J Sellau, M Groneberg, H Fehling, T Thye, S Hoenow, C Marggraff, M Weskamm, C Hansen, S Stanelle-B, S Kuehl, J Noll, V Wolf, NG Metwally, SH Hagen, C Dorn, J Wernecke, H Ittrich, E Tannich, T Jacobs, I Bruchhaus, M Altfeld, H Lotter Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1 Nat Commun, 2020-07-10;11(1):3459. 2020-07-10 [PMID: 32651360] (In Vivo, Mouse)
• JW Shin, MA Kwon, J Hwang, SJ Lee, JH Lee, HJ Kim, KB Lee, SJ Lee, EM Jeong, JH Chung, IG Kim Keratinocyte transglutaminase 2 promotes CCR6+ &amp;gamma&amp;deltaT-cell recruitment by upregulating CCL20 in psoriatic inflammation Cell Death Dis, 2020-04-30;11(4):301. 2020-04-30 [PMID: 32355189] (Bioassay, Mouse)
• C Owen-Woods, R Joulia, A Barkaway, L Rolas, B Ma, AF Nottebaum, KP Arkill, M Stein, T Girbl, M Golding, DO Bates, D Vestweber, MB Voisin, S Nourshargh Local microvascular leakage promotes trafficking of activated neutrophils to remote organs J. Clin. Invest., 2020-05-01;0(0):. 2020-05-01 [PMID: 31971917] (Neutralization, Mouse)
• Germana Lentini, Agata Famà, Carmelo Biondo, Nastaran Mohammadi, Roberta Galbo, Giuseppe Mancuso et al. Neutrophils Enhance Their Own Influx to Sites of Bacterial Infection via Endosomal TLR-Dependent Cxcl2 Production The Journal of Immunology 2/1/2020 [PMID: 31852751]
• L Chen, J Gu, Y Qian, M Li, Y Qian, M Xu, J Li, Y Wen, L Xia, J Li, Q Xia, X Kong, H Wu Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell Mediated Hepatitis via Compensatory Up-regulation of CXCR2 Related Chemokine Activity Cell Mol Gastroenterol Hepatol, 2019-01-07;0(0):. 2019-01-07 [PMID: 30630119] (Neutralization, Mouse)
• U Kulkarni, RL Zemans, CA Smith, SC Wood, JC Deng, DR Goldstein Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality Mucosal Immunol, 2019-01-07;12(2):545-554. 2019-01-07 [PMID: 30617300] (Neutralization, Mouse)
• Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot et al. Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis Immunity 12/18/2018 [PMID: 30446388]
• G Andonegui, EL Zelinski, CL Schubert, D Knight, LA Craig, BW Winston, SC Spanswick, B Petri, CN Jenne, JC Sutherland, R Nguyen, N Jayawarden, MM Kelly, CJ Doig, RJ Sutherland, P Kubes Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment JCI Insight, 2018-05-03;3(9):. 2018-05-03 [PMID: 29720578] (Neutralization, Mouse)
• EE Hornick, B Banoth, AM Miller, ZR Zacharias, N Jain, ME Wilson, KN Gibson-Cor, KL Legge, GA Bishop, FS Sutterwala, SL Cassel Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection J. Immunol., 2017-12-27;0(0):. 2017-12-27 [PMID: 29282312] (Neutralization, Mouse)
• Zeguang Zheng, Yafei Qi, Xiaoming Xu, Hua Jiang, Zhengtu Li, Quan Yang et al. Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation Journal of Thoracic Disease 8/26/2017 [PMID: 28839985]
• R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972. 2017-08-09 [PMID: 28793286] (ELISA Development (Capture), Mouse)
• KW Nowicki, K Hosaka, FJ Walch, EW Scott, BL Hoh M1 macrophages are required for murine cerebral aneurysm formation J Neurointerv Surg, 2017-02-14;0(0):. 2/14/2017 [PMID: 28196918]
• Elena Farmaki Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived CCL3 Cancer Lett, 2016-12-29;0(0):. 2016-12-29 [PMID: 28041977] (Neutralization, Mouse)
• Clara Jana-Lui Busch Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice Hepatology, 2017-02-03;0(0):. 2017-02-03 [PMID: 27981604] (ELISA Development (Capture), Mouse)
• Riva Dill, Ameae M. Walker Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland Journal of Mammary Gland Biology and Neoplasia 3/1/2017 [PMID: 27900586]
• Tyler K. Ulland, Nidhi Jain, Emma E. Hornick, Eric I. Elliott, Gwendolyn M. Clay, Jeffrey J. Sadler et al. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment Nature Communications 10/25/2016 [PMID: 27779193]
• Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus Proc Natl Acad Sci USA, 2016-08-15;0(0):. 2016-08-15 [PMID: 27528685] (Flow Cytometry, Neutralization, Mouse)
• Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype PLoS ONE, 2016-08-15;11(8):e0159986. 2016-08-15 [PMID: 27525971] (Bioassay, Neutralization, Mouse)
• The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity Sci Rep, 2016-07-21;6(0):29994. 2016-07-21 [PMID: 27444332] (Neutralization, Mouse)
• L Seifert, G Werba, S Tiwari, NN Giao Ly, S Alothman, D Alqunaibit, A Avanzi, R Barilla, D Daley, SH Greco, A Torres-Her, M Pergamo, A Ochi, CP Zambirinis, M Pansari, M Rendon, D Tippens, M Hundeyin, VR Mani, C Hajdu, D Engle, G Miller The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression Nature, 2016-04-06;532(7598):245-9. 2016-04-06 [PMID: 27049944] (Neutralization, Mouse)
• Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, Walker S, Gregory L, Lloyd C Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity, 2015-11-17;43(5):945-58. 2015-11-17 [PMID: 26588780] (ELISA Development (Capture), Mouse)
• Kamil W. Nowicki, Koji Hosaka, Yong He, Peter S. McFetridge, Edward W. Scott, Brian L. Hoh A novel high-throughput in vitro model for identifying hemodynamic-induced inflammatory mediators of cerebral aneurysm formation Hypertension 12/1/2014 [PMID: 25225207]
• Lochhead R, Ma Y, Zachary J, Baltimore D, Zhao J, Weis J, O'Connell R, Weis J MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog, 2014-06-26;10(6):e1004212. 2014-06-26 [PMID: 24967703] (ELISA Development, Mouse)
• West D, Del Rosso C, Yin X, Stuart P CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. J Immunol, 2014-01-17;192(4):1762-7. 2014-01-17 [PMID: 24442436] (Neutralization, Mouse)
• Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol, 2013-04-15;190(10):5329-36. 2013-04-15 [PMID: 23589623] (ELISA Development (Capture), Mouse)
• Junkins R, MacNeil A, Wu Z, McCormick C, Lin T Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol, 2013-04-15;190(10):5178-86. 2013-04-15 [PMID: 23589609] (ELISA Development (Capture), Mouse)
• Hee Jung Kim, Jae Seok Jeong, So Ri Kim, Seung Yong Park, Han Jung Chae, Yong Chul Lee Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-kappa B/HIF-1 alpha signaling pathway Scientific Reports 1/28/2013 [PMID: 23359618]
• Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-01-25;58(2):169-77. 2012-01-25 [PMID: 22277799] (Luminex Development, Mouse)
• Roy M, Richard JF, Dumas A, Vallieres L CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation, 2012-01-23;9(0):18. 2012-01-23 [PMID: 22269426] (Neutralization, Mouse)
• Cheung R, Shen F, Phillips JH, McGeachy MJ, Cua DJ, Heyworth PG, Pierce RH Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J. Clin. Invest., 2011-10-17;121(11):4446-61. 2011-10-17 [PMID: 22005300] (Neutralization, Mouse)
• Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011-10-01;179(6):2730-9. 2011-10-01 [PMID: 21967814] (ELISA Development, Mouse)
• Summers SA, van der Veen BS, O'Sullivan KM Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int., 2010-09-15;78(12):1263-74. 2010-09-15 [PMID: 20844472] (Neutralization, Mouse)
• Chou RC, Kim ND, Sadik CD Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity, 2010-08-27;33(2):266-78. 2010-08-27 [PMID: 20727790] (IHC-P, Mouse)
• Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9. 2009-03-16 [PMID: 19289819] (ELISA Development, Mouse)
• Wieland CW, van der Windt GJ, Florquin S, McKenzie AN, van der Poll T ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect., 2009-03-13;11(4):524-30. 2009-03-13 [PMID: 19286469] (ELISA Development, Mouse)
• Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D'Acquisto F Interleukin 17 sustains rather than induces inflammation. Biochem. Pharmacol., 2008-11-25;77(5):878-87. 2008-11-25 [PMID: 19073154] (Neutralization, Mouse)
• Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology, 2008-04-03;125(2):272-9. 2008-04-03 [PMID: 18393969] (ELISA Development, Mouse)
• De Filippo K, Henderson RB, Laschinger M, Hogg N Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J. Immunol., 2008-03-15;180(6):4308-15. 2008-03-15 [PMID: 18322244] (IHC-P, Neutralization, Mouse)
• Scortegagna M, Cataisson C, Martin RJ, Hicklin DJ, Schreiber RD, Yuspa SH, Arbeit JM HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood, 2008-01-16;111(7):3343-54. 2008-01-16 [PMID: 18199827] (Neutralization, Mouse)
• Wengner AM, Pitchford SC, Furze RC, Rankin SM The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood, 2007-10-10;111(1):42-9. 2007-10-10 [PMID: 17928531] (Neutralization, Mouse)
• Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J. Biol. Chem., 2007-10-02;282(49):35502-9. 2007-10-02 [PMID: 17911102] (Immunoprecipitation, Mouse)
• Cunha TM, Verri WA, Jr, Fukada SY, Guerrero AT, Santodomingo-Garzon T, Poole S, Parada CA, Ferreira SH, Cunha FQ TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor. Eur. J. Pharmacol., 2007-07-13;573(1):221-9. 2007-07-13 [PMID: 17669394] (ELISA Development, Mouse)
• Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, Ito T, Matsukawa A Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol., 2006-12-15;177(12):8650-7. 2006-12-15 [PMID: 17142765] (ELISA Development, Mouse)
• Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm. Res., 2006-11-01;55(11):457-64. 2006-11-01 [PMID: 17122962] (ELISA Development, Mouse)
• Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect. Immun., 2006-09-18;74(12):6730-8. 2006-09-18 [PMID: 16982824] (ELISA Development, Mouse)
• Ramos CD, Fernandes KS, Canetti C, Teixeira MM, Silva JS, Cunha FQ Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur. J. Immunol., 2006-08-01;36(8):2025-34. 2006-08-01 [PMID: 16856209] (ELISA Development, Mouse)
• Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA Development, Mouse)
• Gao H, Hoesel LM, Guo RF, Rancilio NJ, Sarma JV, Ward PA Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J. Immunol., 2006-07-01;177(1):612-20. 2006-07-01 [PMID: 16785559] (ELISA Development, Mouse)
• Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J. Immunol., 2005-08-15;175(4):2589-97. 2005-08-15 [PMID: 16081833] (Western Blot, Mouse)
• Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)
• Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA Development, Mouse)
• Guo RF, Lentsch AB, Warner RL, Huber-Lang M, Sarma JV, Hlaing T, Shi MM, Lukacs NW, Ward PA Regulatory effects of eotaxin on acute lung inflammatory injury. J. Immunol., 2001-04-15;166(8):5208-18. 2001-04-15 [PMID: 11290805] (ELISA Development, Mouse)
• Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. J. Immunol., 2001-01-15;166(2):1233-40. 2001-01-15 [PMID: 11145706] (Neutralization, Mouse)

Bioinformatics

• Gene Symbol: Cxcl1
• Uniprot:
  • P12850()