CXCL1/GRO alpha/KC/CINC-1 Antibody (124014)

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Recombinant Mouse CXCL1/KC (Catalog # 453-KC) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR2 in a dose-dependent manner (orange line). The amount of cells that migrated through to ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, B/N
Clone
124014
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

CXCL1/GRO alpha/KC/CINC-1 Antibody (124014) Summary

Immunogen
E. coli-derived recombinant mouse CXCL1/GRO alpha /KC/CINC-1
Arg20-Lys96
Accession # P12850
Specificity
Detects mouse CXCL1 in Western blots. Does not cross-react with recombinant human CXCL2, 3, 5, 6, 8, 9, 10, 11, 12/SDF-1 alpha, 12/SDF-1 beta, 13, recombinant mouse CXCL1, 2, 6, 9, 10, 11, 12/SDF-1 alpha , 13, 15, recombinant rat (rr) CXCL2, rrCXCL3/CINC-2 alpha, rrCXCL3/CINC-2 beta, rrCXCL5, or recombinant porcine CXCL8.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
Cxcl1
Purity
Protein A or G purified from hybridoma culture supernatant
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Neutralization 1-5 ug/mL
Publications
Read Publications using
MAB4531 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL1/GRO alpha/KC/CINC-1 Antibody (124014)

  • CINC1
  • CINC-1
  • CXCL1
  • GRO alpha
  • KC
  • MGSA-alpha

Background

CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXCL1/GRO alpha/KC/CINC-1 Antibody (MAB4531)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IHC, In vivo.


Filter By Application
IHC
(1)
In vivo
(5)
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Filter By Species
Mouse
(6)
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Showing Publications 1 - 6 of 6.
Publications using MAB4531 Applications Species
Aeffner F, Davis I Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice. PLoS ONE, 2012;7(10):e46660. 2012 [PMID: 23056391] (In vivo,, Mouse) In vivo Mouse
Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J. Exp. Med., 2012;209(6):1219-34. 2012 [PMID: 22615129] (IHC,, Mouse) IHC Mouse
Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am. J. Pathol., 2011;179(6):2730-9. 2011 [PMID: 21967814] (In vivo,, Mouse) In vivo Mouse
Breslow JM, Meissler JJ, Hartzell RR Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect. Immun., 2011;79(8):3317-27. 2011 [PMID: 21576323] (In vivo,, Mouse) In vivo Mouse
Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. J. Lipid Res., 2011;52(7):1307-18. 2011 [PMID: 21521824] (In vivo,, Mouse) In vivo Mouse
Traylor ZP, Yu EN, Davis IC Respiratory syncytial virus induces airway insensitivity to beta-agonists in BALB/c mice. Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(3):L437-45. 2010 [PMID: 19965982] (In vivo,, Mouse) In vivo Mouse

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Bioinformatics

Gene Symbol Cxcl1
Entrez
Uniprot