CTRP2 Antibody

Western Blot: CTRP2 Antibody [NBP1-02999] - Western blot of CTRP2 in 3T3 (Balb) cell lysate with CTRP2 Antibody at (A) 1, (B) 2, and (C) 4 ug/ml.

Immunohistochemistry-Paraffin: CTRP2 Antibody [NBP1-02999] - Staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Discontinued

CTRP2 Antibody Summary

• Immunogen: A 16 amino acid synthetic peptide near the center of human CTRP2. The immunogen is located within amino acids 140 - 190 of CTRP2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: C1QTNF2
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 2-4 ug/ml
• Application Notes: Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CTRP2 Antibody

• C1q and tumor necrosis factor related protein 2
• C1QTNF2
• complement-c1q tumor necrosis factor-related protein 2
• CTRP2
• CTRP2complement C1q tumor necrosis factor-related protein 2
• zacrp2

Background

Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-a-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C1QTNF2
• Entrez:
  • 114898(Human)
  • 69183(Mouse)
• Uniprot:
  • Q9BXJ5()