COUP-TF II/NR2F2 Antibody

Product Discontinued

COUP-TF II/NR2F2 Antibody Summary

• Immunogen: The antiserum was produced against synthesized peptide derived from human COT2. The immunogen region is: N-terminal.
• Specificity: COT2 Antibody detects endogenous levels of total COT2 protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NR2F2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunocytochemistry/ Immunofluorescence 1:100-1:500
  • Immunohistochemistry 1:50-1:100
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Western Blot 1:500-1:1000
• Theoretical MW: 45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for COUP-TF II/NR2F2 Antibody

• Apolipoprotein A-I regulatory protein 1
• ARP-1
• ARP1ADP-ribosylation factor related protein 1
• chicken ovalbumin upstream promoter transcription factor 2
• COUP transcription factor 2
• COUP transcription factor II
• COUPTF II
• COUP-TF II
• COUP-TF2
• COUPTFB
• COUPTFII
• COUP-TFII
• MGC117452
• NR2F2
• Nuclear receptor subfamily 2 group F member 2
• nuclear receptor subfamily 2, group F, member 2
• SVP40
• TFCOUP2apolipoprotein AI regulatory protein 1

Background

COUP-TFII, a NR2 Hepatocyte NF4-Like receptor, has been shown to affect neuronal development and differentiation, homeostasis in various human tissues, mesenchymal-epithelial interactions during organogenesis, and the development of the cardiovascular system. COUP-TFII interacts with and modulates several nuclear receptors, including estrogen receptor alpha (ER alpha), thyroid hormone receptors (TR), PPAR alpha, and retinoic acid receptors (RAR). Mice lacking COUP-TFII show abnormal heart and vascular development. COUP-TFII expression has been documented in human adrenal, lung, kidney, liver, spleen, skeletal muscle, and breast. ESTs have been isolated from human tissue libraries, including cancerous adrenal, bladder, brain, breast, colon, head/neck, kidney, lung, ovary, pancreas, pituitary, prostate, skeletal muscle, skin, smooth muscle, stomach, synovium, and uterus, and normal brain, adipose, adrenal, blood, brain, breast, cervix, ear, embryo, gallbladder, ganglion, heart, kidney, liver/spleen, lung, ovary, placenta, prostate, skin, spleen, testis, uterus, and vessel.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for COUP-TF II/NR2F2 Antibody (NBP1-67885)(2)

Publications using NBP1-67885

• Bai H, Hu H, Guo J et al. Polyester vascular patches acquire arterial or venous identity depending on their environment J Biomed Mater Res A 2017-09-06 [PMID: 28877393] (Rat)
• Bai H, Wang M, Foster TR et al. Pericardial patch venoplasty heals via attraction of venous progenitor cells Physiol Rep 2016-06-01 [PMID: 27354544] (IF/IHC)

Bioinformatics

• Gene Symbol: NR2F2
• Uniprot:
  • P24468(Human)