COP9 signalosome complex subunit 2 Antibody

Images

 
Western Blot: COP9 signalosome complex subunit 2 Antibody [NB100-1238] - 3T3 lysates (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Immunohistochemistry: COP9 signalosome complex subunit 2 Antibody [NB100-1238] - In paraffin embedded Human Thyroid Gland shows nclear and cytoplasm staining in activated epithelial cells Recommended concentration ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

COP9 signalosome complex subunit 2 Antibody Summary

Immunogen
Peptide with sequence C-LNSLNQAVVSKLA corresponding to C-Terminus according to NP_001137359.1.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
COPS2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Immunohistochemistry 3 - 5 ug/ml
  • Immunohistochemistry-Paraffin 3 - 5 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 48 kDa band observed in human brain, mouse brain lysates and in lysates of mouse putuitary cell line NIH3T3 (calculated MW of 51.6 kDa band according to NP_004227.1). IHC-P: Human thyroid gland shows nclear and cytoplasm staining in activated epithelial cells
Control
COP9 signalosome complex subunit 2 Overexpression Lysate
Publications
Read Publications using NB100-1238.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for COP9 signalosome complex subunit 2 Antibody

  • Alien homolog
  • ALIEN
  • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
  • COP9 signalosome complex subunit 2
  • CSN2JAB1-containing signalosome subunit 2
  • SGN2TR-interacting protein 15
  • Signalosome subunit 2
  • thyroid receptor interacting protein 15
  • Thyroid receptor-interacting protein 15
  • TRIP15TRIP-15

Background

TRIP15 is an essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP. TRIP15 is also involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for COP9 signalosome complex subunit 2 Antibody (NB100-1238)(2)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

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Bioinformatics

Gene Symbol COPS2
Entrez
Uniprot
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