Complement Factor H-related 5/CFHR5 Antibody (390513) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, IP
• Clone: 390513
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Complement Factor H-related 5/CFHR5 Antibody (390513) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 5/CFHR5
  Glu19-Glu569
  Accession # Q9BXR6
• Specificity: Detects human Complement Factor H-related 5/CFHR5 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor H-related 5/CFHR5 Antibody (390513) [Alexa Fluor® 647]

• CFHL5
• CFHL5factor H-related protein 5
• CFHR5
• Complement Factor Hrelated 5
• Complement Factor H-related 5
• FHR5
• FHR-5complement factor H-related protein 5
• FHR5MGC133240
• FLJ10549

Background

Complement factor H-related protein 5 (FHR-5 or CFHR5) is a 65 kDa member of the factor H-related protein family.  It is secreted by the liver and circulates either free or bound to HDL.  It is unique among FHR proteins in that it associates with complexes that arise from complement activation.  It promotes C3b cleavage and blocks C3 convertase activity.  Human CFHR5 is 551 amino acids (aa) in length.  It contains nine, 60 aa SUSHI-, or short consensus repeats, plus 18 intrachain disulfide bonds. SUSHI repeats 5-7 (aa 267-444) reportedly mediate CFHR5 binding to CRP and heparin.  The complement interaction site(s) is unknown.  Human CFHR5 shares 64% aa sequence identity with canine CFHR5.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.