Complement Component C5a R1 Antibody (S5/1)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, Func, IHC, IHC-P
Clone
S5/1
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Complement Component C5a R1 Antibody (S5/1) Summary

Immunogen
Synthetic peptide comprising the N-terminal domain of the C5aR (Met1-Asn31)
Localization
Integral membrane protein.
Specificity
The has been shown to inhibit the binding of C5a to its receptor.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
C5AR1
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Functional
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Flow Cytometry, Western Blot, Inhibition Assay, Immunohistochemistry-Paraffin In WB detects a band of approximately 45 kDa (predicted molecular weight: 42 kDa).
Positive Control
Complement Component C5a R1 Lysate (NBL1-08482)
Publications
Read Publications using NB120-11867.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein G purified

Alternate Names for Complement Component C5a R1 Antibody (S5/1)

  • C5a anaphylatoxin chemotactic receptor
  • C5A
  • C5aR
  • C5a-R
  • C5AR1
  • C5ARC5a anaphylatoxin receptor
  • C5R1C5a ligand
  • CD88 antigen
  • CD88
  • complement component 5 receptor 1 (C5a ligand)
  • complement component 5 receptor 1
  • complement component 5a receptor 1
  • Complement Component C5a R1
  • Complement Component C5aR1

Background

The human anaphylatoxin C5a is a 74 residue glycopeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a can be demonstrated, rendering this molecule an important mediartor of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP binding coupled receptor that belongs to the rhodopsin supergene family. C5a receptor 1 expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. ESTs have been isolated from B cell/lung/testis, nerve, and placenta libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Complement Component C5a R1 Antibody (NB120-11867)(2)


Showing Publications 1 - 2 of 2.
Publications using NB120-11867 Applications Species
Oppermann M et al. Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. J Immunol, 151:3785. 1993 [PMID: 8376805]
Oppermann, M et al. Antibodies from the myeloid panel that react with the C5a receptor antagonize C5a biological activity. gmp013. 2009

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol C5AR1
Entrez