Complement Component C1s Antibody (M241)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, B/N, Flow, IA, IHC, IHC-Fr, IHC-P
Clone
M241
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Complement Component C1s Antibody (M241) Summary

Immunogen
The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s.
Specificity
The antibody binds specifically to the active centre of C1s.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
C1S
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Blocking/Neutralizing 50-200 molar excess
  • Flow Cytometry 1:10-1:1000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For inhibition of biological activity dilutions have to be made according to the amounts C1s to be inactivated.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS containing 0.1% bovine serum albumin.
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for Complement Component C1s Antibody (M241)

  • basic proline-rich peptide IB-1
  • C1 esterase
  • C1S
  • complement C1s subcomponent
  • Complement component 1 subcomponent s
  • complement component 1, s subcomponent
  • Complement Component C1s
  • EC 3.4.21
  • EC 3.4.21.42
  • FLJ44757

Background

Monoclonal antibody M241 reacts with an epitope on human C protein activated C1s, a subcomponent of the first component of C (C1). Activated C1s is a glycosylated single-polypeptide zymogen of 85 kD. Activation of the proenzyme C1s occurs through cleavage by the active form of C1r. The activated protease, activated C1s, consists of a disulfide-linked H chain and a L chain. Activated C1s is a serine protease and its catalytic site is located in the L chain. Activation of the classical C pathway is triggered by activated C1s which cleaves C4 and C2 to form the C3 convertase, C4bC2a. The epitope recognised by the antibody M241 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M241 blocks C4 activation and C4 binding to activated C1s. The antibody binds specifically to the active centre of C1s.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol C1S
Entrez