Complement C4c Native Protein

Product Discontinued

Complement C4c Native Protein Summary

• Description: Native human C4c.
  
  

  Source:Human

  Amino Acid Sequence:UniProt P0C0L5

• Preparation Method: Purified Ig prepared by affinity chromatography
• Source: Human serum
• Protein/Peptide Type: Native Protein
• Gene: C4B
• Purity: >95%, by SDS-PAGE

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Store at -20C.
• Buffer: PBS
• Concentration: 1.8 mg/ml
• Purity: >95%, by SDS-PAGE

Alternate Names for Complement C4c Native Protein

• basic C4
• Basic complement C4
• C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
• C4B1
• C4B12
• C4B2
• C4B3
• C4FMGC164979
• CH
• Chido form of C4
• CO4C4B5
• complement C4-B
• complement C4B1a
• complement component 4B (Chido blood group)
• complement component 4B
• CPAMD3FLJ60561
• EC 2.1.1.144
• EC 2.7.11

Background

C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa, beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: C4B