CMG-2/ANTXR2 Antibody (406510) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: ELISA
• Clone: 406510
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

CMG-2/ANTXR2 Antibody (406510) [Alexa Fluor® 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CMG-2/ANTXR2
  Ser22-Arg200
  Accession # P58335
• Specificity: Detects human CMG-2/ANTXR2 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CMG-2/ANTXR2 Antibody (406510) [Alexa Fluor® 488]

• anthrax toxin receptor 2
• ANTXR2
• Capillary morphogenesis gene 2 protein
• capillary morphogenesis protein 2
• cI-35
• CMG2
• CMG-2
• CMG2MGC111533
• CMG-2MGC45856
• FLJ31074
• ISH
• JHF
• JHS

Background

Capillary Morphogenesis Protein 2 (CMG-2) is an anthrax toxin receptor (ATR) family protein that contains a von Willebrand factor type A domain. As a result of alternative splicing, at least four isoforms of secreted or type I membrane proteins exist. CMG-2 is widely expressed in human tissues. It binds selectively to collagen type IV and laminin and is also capable of binding the protective antigen (PA) of Bacillus Anthracis in a divalent cation-dependent manner. Soluble CMG-2 is a potent antitoxin and may be used as a treatment of anthrax. Within the region used as immunogen, human and mouse CMG-2 share 76% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.