Claudin-11 Antibody (1102132) [DyLight 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 1102132
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 405

Claudin-11 Antibody (1102132) [DyLight 405] Summary

• Immunogen: Synthetic Peptide
  Accession # O75508
• Specificity: Detects a synthetic peptide specific for human Claudin-11 around amino acid 200 in Direct ELISA.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Claudin-11 Antibody (1102132) [DyLight 405]

• claudin 11
• Claudin11
• Claudin-11
• CLDN11
• Oligodendrocyte-specific protein
• OSP
• OSPOTMoligodendrocyte transmembrane protein
• OTM

Background

Oligodendrocyte specific protein belongs is a major component of central nervous system myelin that is necessary for normal CNS function. The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin 1 through 18, and are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that the Claudin 11 protein determines the permeability between layers of myelin sheaths via focal adhesion and with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.