ChemR23/CMKLR1 Antibody (84939) [Allophycocyanin]

• Applications: Flow
• Clone: 84939
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

ChemR23/CMKLR1 Antibody (84939) [Allophycocyanin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human ChemR23
  Met1-Leu371
  Accession # NP_004063
• Specificity: Detects human ChemR23. Stains human ChemR23-transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG3
• Clonality: Monoclonal
• Host: Mouse
• Gene: CMKLR1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

ChemR23, also known as CMKLR1, is a 47-48 kDa 7-transmembrane member of the rhodopsin, or G-protein coupled receptor family 1. It has restricted expression on select cell types that, in primate, include adipocytes, astrocytes, endothelial cells, microglia/macrophages, chondrocytes, monocytes, osteocytes, NK cells, and plasmacytoid plus myeloid dendritic cells. In mouse, would studies show ChemR23 to be expressed by neutrophils and keratinocytes. The universally-agreed on ligand for ChemR23 is Chemerin, a 137 amino acid (aa) non-chemokine product of fibroblasts, platelets, adipocytes and endothelium. The Chermerin:ChemR23 system is suggested to promote chemotaxis for all ChemR23+ cells, and to induce angiogenesis via endothelial cell migration and MMP-2 and -9 activation. There is one alternative splice form that shows a deletion of aa 1 and 2 (NP_004063). Over the extracellular domains of ChemR23, human and mouse share 69% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CMKLR1