CHD8 Recombinant Enzymes

• Reactivity: Hu
• Applications: NULL

CHD8 Recombinant Enzymes Summary

• Description: Human CHD8 (aa 2-2302) fused to a FLAG-tag at the N-terminus. (Uniprot: Q9HCK8-2)
• Source: Sf 9 (baculovirus)
• Protein/Peptide Type: Recombinant Enzymes
• Gene: CHD8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • N/A

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 15% glycerol, 2 mM MgCl2, 0.2 mM EDTA, 1 mM DTT, 10 mM beta-glycerophospate, 0.4 mM PMSF, 1 mM benzamidine and 0.4 mg/ml recombinant human insulin
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for CHD8 Recombinant Enzymes

• ATP-dependent helicase CHD8
• CHD-8
• chromodomain helicase DNA binding protein 8
• DKFZp686N17164
• duplin
• EC 3.6.1
• EC 3.6.1.7
• EC 3.6.4.12
• Helicase with SNF2 domain 1chromodomain-helicase-DNA-binding protein 8
• HELSNF1
• KIAA1564axis duplication inhibitor

Background

CHD8 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD8 has been reported to interact with duplin, a protein involved in the wnt signaling pathway, and CTCF, a protein involved in heterochromatin formation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

FAQs for CHD8 Recombinant Enzymes (NBP3-48870). (Showing 1 - 1 of 1 FAQ).

1. I see that all of your CHD8 antibodies say that they are specific for human. Have any been tested in mouse? I want to know if they have and were found not to be suitable. Ideally, I would like to try one in mouse for immunocytochemistry.
   • We have not tested any of our CHD8 antibodies in mouse samples, and do not have any data to support whether they will work for you or not. If you would like to purchase one to try on your samples, you will qualify for our Innovators Reward Program. Under this program, Novus will provide you a 50% refund on the purchased product as well as a 50% discount on a future product of equal value in exchange for your new data.

Bioinformatics

• Gene Symbol: CHD8