CEACAM3/CD66d Antibody (417009) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 417009
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

CEACAM3/CD66d Antibody (417009) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human CEACAM‑3/CD66d isoform 1
  Lys35-Gly155
  Accession # P40198
• Specificity: Detects human CEACAM‑3/CD66d in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human CEACAM-1, -4, -5, or -6 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CEACAM3/CD66d Antibody (417009) [Alexa Fluor® 647]

• CD66d
• CEA
• CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
• CEACAM-3
• CGM1
• W264
• W282

Background

Carcinoembryonic Antigen-related Cell Adhesion Molecule 3, (CEACAM-3) also known as CD66d and CGM1, is a 35 kDa transmembrane glycoprotein in the CEACAM family of the immunoglobulin superfamily. The extracellular region consists of one Ig-like V-type domain, and the cytoplasmic tail contains one ITAM. CEACAM-3 is upregulated on activated neutrophils and mediates their adhesion to vascular endothelial cells. CEACAM-3 binds the Opa opacity proteins on some Gram negative bacteria, leading to bacterial uptake and neutrophil death. Alternate splicing generates an isoform with a substituted cytoplasmic tail and a potentially secreted isoform that contains a highly charged and Ser/Thr-rich sequence in place of the transmembrane and cytoplasmic regions. Orthologs of human CEACAM-3 have not been identified in other species.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.