CDC73/HRPT2 Antibody

Western Blot: CDC73/HRPT2 Antibody [NBP1-32972] - Sample (30 ug of whole cell lysate) A: Molt-4 7. 5% SDS PAGE; antibody diluted at 1:1000.

• Reactivity: Hu, Mu, Rt, Bv, Ca, Ch, RM, Xp, Ze
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

CDC73/HRPT2 Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human CDC73. The exact sequence is proprietary.
• Localization: Nucleus
• Predicted Species: Mouse (100%), Rat (99%), Chicken (97%), Canine (100%), Xenopus (91%), Zebrafish (90%), Rhesus Macaque (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDC73
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:3000
• Theoretical MW: 61 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (91%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Immunogen affinity purified

Alternate Names for CDC73/HRPT2 Antibody

• C1orf28hyperparathyroidism 2 (with jaw tumor)
• CDC73
• cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae)
• Cell division cycle protein 73 homolog
• chromosome 1 open reading frame 28
• HPTJT
• HPT-JT
• HRPT2
• HRPT2FLJ23316
• Hyperparathyroidism 2 protein
• HYX
• Parafibromin

Background

Parafibromin, the product of gene HPRT2, acts as a tumor suppressor protein by inhibiting cell proliferation and blocking expression of cyclin D1 when overexpressed. Parafibromin has also been shown to bind with the PAF1 complex / RNA polymerase II which is involved with transcription elongation and the RNA processing pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: CDC73