CDC73/HRPT2 Products

Description

Parafibromin, the product of gene HPRT2, acts as a tumor suppressor protein by inhibiting cell proliferation and blocking expression of cyclin D1 when overexpressed. Parafibromin has also been shown to bind with the PAF1 complex / RNA polymerase II which is involved with transcription elongation and the RNA processing pathway.

Bioinformatics

Entrez	79577 Human
Uniprot	NP_078805.3 Human NM_024529 Human Q6P1J9 Human Q6P1J9 (human) Human
Product By Gene ID	79577
Alternate Names	Hyperparathyroidism 2 protein HYX Cell division cycle protein 73 homolog HPTJT parafibromin HRPT2FLJ23316 C1orf28hyperparathyroidism 2 (with jaw tumor) chromosome 1 open reading frame 28 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae)

Diseases related to CDC73/HRPT2

Discover more about diseases related to CDC73/HRPT2.

Neoplasms
Parathyroid Neoplasms
Carcinoma
Parathyroid Gland Adenocarcinoma
Hyperparathyroidism-jaw Tumor Syndrome
Adenoma
Malignant Neoplasms
Hyperparathyroidism, Primary
Parathyroid Gland Adenoma
Jaw Neoplasms
Multiple Endocrine Neoplasia Type 1
Hyperparathyroidism 3
Hypercalcemia
Malignant Paraganglionic Neoplasm
Endocrine Gland Neoplasms
Multiple Endocrine Neoplasia
Neoplasm Metastasis
Germline Mutation Abnormality
Familial Hyperparathyroidism

Pathways for CDC73/HRPT2

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Cell Cycle
Methylation
Pathogenesis
Localization
Cell Growth
Cell Proliferation
Rna Interference
Translation
Histone Modification
Rna Processing
Cell Division
Cell Cycle Arrest
Mrna Processing
Invasive Growth
Histone Methylation
Histone H2b Ubiquitination
S Phase
Histone Monoubiquitination
Regulation Of Gene Expression
Reverse Transcription

Research Areas for CDC73/HRPT2

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Cancer
Tumor Suppressors

PTMs for CDC73/HRPT2

Learn more about PTMs related to CDC73/HRPT2.

Methylation
Phosphorylation
Cleavage
Ubiquitination
Dephosphorylation

Bioinformatics Tool for CDC73/HRPT2

Discover related pathways, diseases and genes to CDC73/HRPT2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.