CDC7 Antibody

Immunohistochemistry-Paraffin: CDC7 Antibody [NLS7980] - Anti-CDC7 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: CDC7 Antibody [NLS7980] - Analysis of anti-CDC7 antibody with human lung, non-small cell carcinoma.

Immunohistochemistry-Paraffin: CDC7 Antibody [NLS7980] - Anti-CDC7 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Product Discontinued

CDC7 Antibody Summary

• Immunogen: Synthetic 19 amino acid peptide from kinase domain of human CDC7.
• Specificity: Human CDC7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (95%), Rat (95%), Hamster (95%), Monkey (95%), Primate (100%), Opossum (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CDC7
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 6.5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Elephant (100%), Panda (100%), Platypus (95%), Turkey (89%), Chicken (89%)< Lizard (89%), Xenopus (89%), Stickleback (84%), Pufferfish (84%), Zebrafish (84%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for CDC7 Antibody

• CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
• CDC7 cell division cycle 7 (S. cerevisiae)
• CDC7
• CDC7L1
• CDC7L1MGC117361
• CDC7-related kinase
• cell division cycle 7 (S. cerevisiae)
• cell division cycle 7 homolog (S. cerevisiae)
• cell division cycle 7-like protein 1
• cell division cycle 7-related protein kinase
• EC 2.7.11.1
• HsCdc7
• Hsk1
• huCdc7
• MGC126237
• MGC126238

Background

CDC7L1, CDC7 type protein kinase, regulates firing of the origins of initiation in DNA replication. CDC7L1 forms a complex with a Dbf4-related regulatory subunit to generate an active kinase. Mini-chromosome maintenance protein (MCM) is the major physiological target of Cdc7L1. At least three mRNA variants have been reported. Overexpression of the CDC7L1 protein may be associated with neoplastic transformation for some tumors. CDC7L1 has been documented in a wide range of tissues. One variant is expressed ubiquitously in human tissues while at least one other has been shown to be testis-specific. ESTs have been isolated from several tissue libraries, including normal embryo, gallbladder, lymph node and thymus and cancerous duodenum and embryo.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CDC7
• Entrez:
  • 8317(Human)