CD5L Antibody - BSA Free

Western Blot: CD5L Antibody [NBP1-76700] - Human lymph node tissue lysate with CD5L antibody at (A) 1, (B) 2 and (C) 4 ug/ml.

Immunohistochemistry-Paraffin: CD5L Antibody [NBP1-76700] - Human lymph node tissue with CD5L antibody at 2 ug/ml.

Immunocytochemistry/ Immunofluorescence: CD5L Antibody - BSA Free [NBP1-76700] - Immunofluorescence of CD5L in Human Lymph Node cells with CD5L antibody at 20 ug/mL.

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

CD5L Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit CD5L Antibody - BSA Free (NBP1-76700) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. Anti-CD5L Antibody: Cited in 2 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human AIM. The immunogen is located within amino acids 60 - 110 of AIM. Amino Acid Squence: PSGILYEPPAEKEQKV
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CD5L
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Immunohistochemistry 2 ug/ml
  • Immunohistochemistry-Paraffin 2 ug/ml
  • Western Blot 1-4 ug/ml
• Control Peptide:

  CD5L Peptide (NBP1-76700PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for CD5L Antibody - BSA Free

• AIM
• API6
• apoptosis inhibitor 6
• CD5 antigen-like (scavenger receptor cysteine rich family)
• CD5 antigen-like
• CD5 molecule-like
• CD5L
• CT-2
• IgM-associated peptide
• PRO229
• Spalpha
• SP-alpha

Background

Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CD5L Antibody (NBP1-76700)(2)

Publications using NBP1-76700

• Chiaki Kajiwara, Ayako Shiozawa, Naohisa Urabe, Tetsuo Yamaguchi, Soichiro Kimura, Yoshikiyo Akasaka, Yoshikazu Ishii, Kazuhiro Tateda Apoptosis Inhibitor of Macrophages Contributes to the Chronicity of Mycobacterium avium Infection by Promoting Foamy Macrophage Formation. Journal of immunology (Baltimore, Md. : 1950) 2023-02-03 [PMID: 36602769]
• Wang Y, Guo B, Guo Y, Qi N et Al. A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads Front Endocrinol (Lausanne) 2022-12-05 [PMID: 36465633]

Bioinformatics

• Gene Symbol: CD5L
• Uniprot:
  • AAD01446(Human)