CD5 Antibody (53-7.3) [Alexa Fluor™ Plus 405]

• Clone: 53-7.3
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 405

CD5 Antibody (53-7.3) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects mouse CD5.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Mouse CD5 has been shown to react with a mouse monomorphic CD5 (Ly-1), a Group B member of the scavenger receptor cysteine-rich protein superfamily (1). CD5 is a 67 kDa type I transmembrane glycoprotein found on thymocytes, T cells, and a subset of B cells but not on NK cells (2‑6). It is likely a ligand of the B cell differentiation antigen CD72 and is known to associate with CD6 (1). Mouse and human extracellular domains share 55% amino acid sequence indentity.

1. Martinez, V.G., et al. (2011) Pharmacol. Rev. 63:967.
2. Ledbetter, J.A. et al. (1980) J. Exp. Med. 152:280.
3. van Ewijk, W. et al. (1981) J. Immunol. 127:2594.
4. Hayakawa, K. et al. (1983) J. Exp. Med. 157:202.
5. Luo, W. et al. (1992) J. Immunol. 148:1630.
6. Lanier, L.L. et al. (1986) J. Immunol. 137:2735.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.