CD5 Products

Description

In humans, CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.

Bioinformatics

Entrez	12507 Mouse 54236 Rat 921 Human
Uniprot	ABM83003 Human ABM83003.1 Human NM_014207 Human NP_055022.2 Human P06127 Human
Product By Gene ID	921
Alternate Names	CD5 antigen (p56-62) CD5 antigen CD5 molecule LEU1T-cell surface glycoprotein CD5 Lymphocyte antigen T1/Leu-1 T1

Research Areas for CD5

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Biology
Cytokine Research
Immunology
Phospho-Specific

Related CD5 Blog Posts

Check out the latest blog posts on CD5.

How To Identify B Cell Subsets Using Flow Cytometry By Victoria OsinskiUsing Flow Cytometry to Identify B Cell SubsetsIdentifying cellular subsets by flow cytometry requires careful and thorough planning in order to ensure the correct subset of cells are identified...    Read more.

Read more CD5 related blogs.