CD5 Products

Antibodies
CD5 Antibody [Unconjugated]
CD5 Antibody [Unconjugated]
AF1636
Species: Hu
Applications: WB, Simple Western, Flow, AgAct, ICC
Host: Goat Polyclonal
CD5 Antibody (7A7)
CD5 Antibody (7A7)
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
CD5 Overexpression Lysate (Na ...
CD5 Overexpression Lysate (Native)
NBL1-08956
Applications: WB
Proteins
CD5 Recombinant Protein Antig ...
CD5 Recombinant Protein Antigen
NBP2-38509PEP
Species: Hu
Applications: AC
CD5 Recombinant Protein Antig ...
CD5 Recombinant Protein Antigen
NBP2-38900PEP
Species: Hu
Applications: AC
CD5 Recombinant Protein
CD5 Recombinant Protein
NBP2-51652
Species: Hu
Applications: PAGE
RNAi
CD5 RNAi
CD5 RNAi
H00000921-R02
Species: Hu

Description

In humans, CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 921
Alternate Names
  • CD5 antigen (p56-62)
  • CD5 antigen
  • T1
  • LEU1T-cell surface glycoprotein CD5
  • Lymphocyte antigen T1/Leu-1
  • CD5 molecule

Research Areas for CD5

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Biology
Cytokine Research
Immunology
Phospho-Specific

Bioinformatics Tool for CD5

Discover related pathways, diseases and genes to CD5. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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