CD3 zeta Antibody (H146-968) [FITC]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications Flow
Clone
H146-968
Clonality
Monoclonal
Host
Armenian Hamster
Conjugate
FITC
Concentration
1.0 mg/ml

CD3 zeta Antibody (H146-968) [FITC] Summary

Immunogen
Synthetic peptide corresponding to amino acids 151-164 of mouse CD3 zeta.
Specificity
The Armenian hamster antibody H146-968 reacts with CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
Isotype
IgG
Clonality
Monoclonal
Host
Armenian Hamster
Gene
CD247
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 2 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
TBS (approx. pH 8.0)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Notes

Store in the dark, avoid prolonged exposure to light.

Alternate Names for CD3 zeta Antibody (H146-968) [FITC]

  • CD247 antigen
  • CD247 antigen, zeta subunit
  • CD247 molecule
  • CD247
  • CD3 zeta
  • CD3H
  • CD3Q
  • CD3z antigen, zeta polypeptide (TiT3 complex)
  • CD3Z
  • CD3ZT-cell receptor T3 zeta chain
  • IMD25
  • T3Z
  • T-cell antigen receptor complex, zeta subunit of CD3
  • T-cell surface glycoprotein CD3 zeta chain
  • TCR Zeta Chain
  • TCRZCD3-ZETA

Background

CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CD247
Entrez