CD28 Antibody (29704-1) [Alexa Fluor® 750]

Product Discontinued

CD28 Antibody (29704-1) [Alexa Fluor® 750] Summary

• Additional Information: Recombinant Monoclonal Antibody. See GMP Antibody Protocols!
• Immunogen: Human T lymphocytes
• Specificity: Detects human CD28 in direct ELISAs
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Purity Statement: Protein G purified

Applications/Dilutions

• Dilutions:
  • T Cell Stimulation

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CD28 Antibody (29704-1) [Alexa Fluor® 750]

• CD28 antigen (Tp44)
• CD28 antigen
• CD28 molecule
• CD28
• MGC138290
• T-cell-specific surface glycoprotein CD28
• Tp44

Background

The Bio-Techne CD28 GMP antibody is derived from the 15e8 clone. CD28 is a critical protein expressed on the surface of T cells that provides a co-stimulatory signal necessary for T cell activation and proliferation. CD28 is structurally similar to CTLA-4, with both molecules exhibiting structural homology to the immunoglobulin (Ig) gene superfamily. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant co-stimulatory pathways that regulate T and B cell responses. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain, and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.