CD24 Antibody (30-F1) [PE]

Product Discontinued

CD24 Antibody (30-F1) [PE] Summary

• Immunogen: Mouse thymus or spleen
• Specificity: Mouse CD24/heat stable antigen (HSA)
• Isotype: IgG2c
• Clonality: Monoclonal
• Host: Rat
• Gene: CD24
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.2 ug/10^6 cells

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS and a stabilizing agent
• Preservative: Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A or G purified

Notes

Protect conjugated forms from light.

Alternate Names for CD24 Antibody (30-F1) [PE]

• CD 24
• CD24 antigen (small cell lung carcinoma cluster 4 antigen)
• CD24 antigen
• CD24 molecule
• CD24
• CD24A
• CD24Asignal transducer CD24
• FLJ22950
• FLJ43543
• MGC75043
• Small cell lung carcinoma cluster 4 antigen

Background

CD24 is expressed in B cells until their terminal differentiation into plasma cells. (1) It has been used widely as a marker to fractionate different B-lineage differentiation stages. (10) CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule. (2-4) The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse. (1, 3) The molecular mass is variable, ranging from 38-70 kDa.3 CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins. (1-4) Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion. (3) This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti-CD24 monoclonal antibody. (6) Recent studies of murine CD24 have assigned a role for CD24/HSA as a ligand for P-selectin, a calcium-dependent lectin. (7)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD24