CCR5 Antibody (45523) [PE]

• Reactivity: Hu
• Applications: IHC
• Clone: 45523
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PE

CCR5 Antibody (45523) [PE] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human CCR5
  Met1-Leu352
  Accession # P51681
• Specificity: Can be used to detect CCR5 present on stimulated human PBMCs only after cells are fixed with 2% formaldehyde. It does not detect CCR5 on unfixed human PBMCs. It does not cross-react with CCR1, CCR2, or CCR3. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see Lee, B. et al., 1999, J. Biol. Chem. 274:9617.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CCR5
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for CCR5 Antibody (45523) [PE]

• C-C CKR-5
• C-C motif chemokine receptor 5 A159A
• CCCKR5
• CC-CKR-5FLJ78003
• CCR5
• CCR-5
• CD195 antigen
• CD195
• chemokine (C-C motif) receptor 5
• chemokine receptor CCR5
• chemr13
• CKR5
• CKR-5
• HIV-1 fusion coreceptor
• IDDM22CMKBR5C-C chemokine receptor type 5

Background

C-C chemokine receptor type 5 (CCR5) is a member of the beta chemokine receptors family of integral membrane proteins. The CCR5 protein is a G protein-coupled receptor which functions as a chemokine receptor in the CC chemokine group.

CCR5 is a major coreceptor for human HIV infection and is predominantly expressed on T cells, macrophages, dendritic cells and microglia. It is likely that CCR5 plays a role in inflammatory responses to infection, though its exact role in normal immune function is unclear.

CCR5 antibodies are useful for HIV infection studies and research on immune responses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CCR5