Cathepsin A/Lysosomal Carboxypeptidase A Antibody (191424) [Alexa Fluor™ Plus 647]

• Reactivity: Mu
• Clone: 191424
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor Plus 647

Cathepsin A/Lysosomal Carboxypeptidase A Antibody (191424) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects mouse Cathepsin A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Cathepsin A or recombinant mouse DPPIV/CD26 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cathepsin A/Lysosomal Carboxypeptidase A Antibody (191424) [Alexa Fluor™ Plus 647]

• beta-galactosidase 2
• beta-galactosidase protective protein
• Carboxypeptidase C
• Carboxypeptidase L
• Cathepsin A
• cathepsin ANGBE
• CTSA
• EC 3.4.16
• EC 3.4.16.5
• GLB2
• GSL
• Lysosomal Carboxypeptidase A
• lysosomal protective protein
• PPCA
• PPGBprotective protein for beta-galactosidase (galactosialidosis)
• Protective protein cathepsin A
• Protective protein for beta-galactosidase

Background

Cathepsin A/lyososomal carboxypeptidase A is a member of the serine carboxypeptidase family (1, 2). Cathepsin A is a multifunctional enzyme that expresses deaminidase and esterase activities at neutral pH and carboxypeptidase activity at acidic pH. Also known as protective protein, its association with beta -galactosidase ( beta -gal) and neuraminidase is essential for beta -gal stability and neuraminidase activation in the lysosomes. Inherited deficiency of cathepsin A causes the lysosomal storage disorder galactosialidosis, characterized by a combined secondary deficiency of beta -gal and neuraminidase. Cathepsin A is capable of hydrolyzing a variety of bioactive peptide hormones including tachykinins, indicating that extralysosomal cathepsin A plays a role in regulation of functions of these molecules (3). Cathepsin A is synthesized as a single-chain precursor and processed into heavy (32 kDa) and light (20 kDa) chains, which are linked by disulfide bonds.

1. Galjart, et al. (1990) J. Biol. Chem. 265:4678.
2. Pshezhetsky (1998) in Handbook of Proteolytic Enzymes (ed. Barrett, Rawlings, Woessner) pp. 393, Academic Press, San Diego.
3. Hiraiwa (1999) Cell. Mol. Life. Sci. 56:894.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.