Cathepsin A/Lysosomal Carboxypeptidase A Products

Antibodies
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
AF1049
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
NBP1-89728
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
MAB1123
Species: Mu
Applications: WB, IP
Host: Rat Monoclonal
Formulation Catalog # Availability Price  
Lysates
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
NBL1-09586
Species: Hu
Applications: WB
Proteins
Recombinant Human Cathepsin A ...
Recombinant Human Cathepsin A/Lyso...
1049-SE
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Mouse Cathepsin A ...
Recombinant Mouse Cathepsin A/Lyso...
9789-SE
Species: Mu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
NBP1-89728PEP
Species: Hu
Applications: AC
RNAi
Cathepsin A/Lysosomal Carboxy ...
Cathepsin A/Lysosomal Carboxypepti...
H00005476-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Lysosomal protective protein/cathepsin A (PPCA) is a lysosomal serine carboxypeptidase that forms an intralysosomal enzyme-complex with b-galactosidase and neuraminidase (NEU1). PPCA is synthesized as a 54-kDa precursor/zymogen, and proteolytically cleaved in the lysosome into a catalytically active 32- and 20-kDa two-chain enzyme. The enzyme has cathepsin A activity at acidic pH but maintains also a deamidase/esterase activity at neutral pH. Furthermore, the human enzyme, purified from platelets and lymphocytes, has been shown to function on the inactivation of selected neuropeptides, like substance P, oxytocin, and endothelin I. The autosomal recessive genetic deficiency of PPCA causes galactosialidosis, a neurodegenerative lysosomal storage disorder, resulting in the secondary deficiencies of b-galactosidase and NEU1.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Mouse
Product By Gene ID 5476
Alternate Names
  • GSL
  • EC 3.4.16
  • GLB2
  • Protective protein for beta-galactosidase
  • EC 3.4.16.5
  • lysosomal protective protein
  • PPCA
  • beta-galactosidase protective protein
  • Protective protein cathepsin A
  • beta-galactosidase 2
  • Carboxypeptidase L
  • Carboxypeptidase C
  • PPGBprotective protein for beta-galactosidase (galactosialidosis)
  • cathepsin ANGBE

PTMs for Cathepsin A/Lysosomal Carboxypeptidase A

Learn more about PTMs related to Cathepsin A/Lysosomal Carboxypeptidase A.

Cleavage
Phosphorylation
Glycosylation
Deamidation
Ribosylation
Deglycosylation

Bioinformatics Tool for Cathepsin A/Lysosomal Carboxypeptidase A

Discover related pathways, diseases and genes to Cathepsin A/Lysosomal Carboxypeptidase A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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