VE-Statin/EGFL7 Antibody

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: LYOPH

VE-Statin/EGFL7 Antibody Summary

• Immunogen: E. coli-derived recombinant human VE-Statin
  Glu21-Ser273
  Accession # BAD01469
• Specificity: Detects human VE-Statin in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant mouse VE-Statin is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: EGFL7
• Purity: Immunogen affinity purified
• Purity Statement: Antigen Affinity-purified
• Endotoxin Note: <0.10 EU per 1 μg of the antibody by the LAL method.

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Immunogen affinity purified
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VE-Statin/EGFL7 Antibody

• EGFL7
• EGF-like protein 7
• EGF-like-domain, multiple 7
• epidermal growth factor-like protein 7
• MEGF7
• MGC111117
• Multiple EGF-like domains protein 7
• Multiple epidermal growth factor-like domains protein 7
• NEU1 protein
• NOTCH4-like protein
• RP11-251M1.2
• Vascular endothelial statin
• VEStatin
• VE-Statin
• ZNEU1

Background

VE-Statin, also known as epidermal growth factor-like domain 7 (EGFL7), is a secreted endothelial-specific protein that is a marker for progenitor, embryonic and adult endothelial cells. Mature soluble VE-Statin is a 41 kDa protein containing an N-terminal cysteine-rich EMI domain, followed by two EGF-like domains and a coiled-coil region. VE-Statin inhibits PDGF-BB-induced smooth muscle cell migration. The amino acid sequence of human VE-Statin is 80% identical to that of mouse VE-Statin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VE-Statin/EGFL7 Antibody (AF3638)(3)

Publications using AF3638

• V Liakouli, P Cipriani, P Di Benedet, N Panzera, P Ruscitti, I Pantano, O Berardicur, F Carubbi, F Esteves, G Mavria, F Del Galdo, R Giacomelli Epidermal Growth Factor Like-domain 7 and miR-126 are abnormally expressed in diffuse Systemic Sclerosis fibroblasts Sci Rep, 2019;9(1):4589. 2019-01-01 [PMID: 30872612] (Western Blot, Human)
• Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation J Biol Chem, 2016;0(0):. 2016-01-01 [PMID: 27650497] (Western Blot, Human)
• Lelievre E, Hinek A, Lupu F, Buquet C, Soncin F, Mattot V VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases. EMBO J., 2009;27(12):1658-70. 2009-01-01 [PMID: 18497746] (ICC, Human)

Bioinformatics

• Gene Symbol: EGFL7
• Uniprot:
  • BAD01469()