Caspr2 Antibody [Biotin]

• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Biotin
• Concentration: LYOPH

Caspr2 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Caspr2 isoform 1
  Pro29-Ala1262
  Accession # Q9UHC6
• Specificity: Detects human Caspr2 in Western blots.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: CNTNAP2
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Contactin-associated protein 2 (Caspr2) is a neuronal membrane protein and member of the neurexin family. Caspr2 is the mammalian homolog of Drosophila Neurexin IV. Caspr2 is believed to be involved in the local differentiation of the axon into distinct functional subdomains. Studies have shown that Caspr2 is essential for clustering of Shaker-type K⁺ channels in the juxtaparanodes of Ranvier. This effect is dependent on the association of Caspr2 with TAG-1, a glycosyl-phosphatidyl-inositol-anchored cell adhesion molecule. Mutations in Caspr2 are associated with the development of autism and related disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CNTNAP2