Caspr2 Antibody [Alexa Fluor® 350]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

Caspr2 Antibody [Alexa Fluor® 350] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Caspr2 isoform 1
  Pro29-Ala1262
  Accession # Q9UHC6
• Specificity: Detects human Caspr2 in direct ELISAs and human, mouse, and rat Caspr2 in Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human Caspr1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Caspr2 Antibody [Alexa Fluor® 350]

• AUTS15
• Caspr2
• CASPR2DKFZp781D1846
• CDFE
• Cell recognition molecule Caspr2
• CNTNAP2
• contactin associated protein-like 2
• contactin-associated protein 2
• contactin-associated protein-like 2
• homolog of Drosophila neurexin IV
• KIAA0868
• NRXN4
• NRXN4Caspr2
• PTHSL1

Background

Caspr2 (CNTNAP2, Contactin-associated protein-like 2 and Cell recognition molecule Caspr2) is a 160-170 kDa glycoprotein, a member of the neurexin family of proteins.  It is predominantly expressed in nervous system and likely play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Caspr2 and closely related molecule Caspr/Paranodin demarcate distinct subdomains in myelinated axons. While contactin-associated protein (Caspr) is present at the paranodal junctions, Caspr2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region.  Over aa 29-1262, human CASPR2 shares 94% aa sequence identity with mouse Caspr2.                    

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.