Caspase-7 Antibody (10-1-62)

Images

 
Western Blot: Caspase-7 Antibody (10-1-62) [NBP1-19230] - Analysis of human Jurkat and Jurkat induced cell lysates probed with AAM-137
Immunohistochemistry: Caspase-7 Antibody (10-1-62) [NBP1-19230] - Human spleen tissue stained with Caspase-7, mAb (10-1-62) at 10ug/ml.
Immunohistochemistry: Caspase-7 Antibody (10-1-62) [NBP1-19230] - Human colon tissue stained with Caspase-7, mAb (10-1-62) at 10ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, IHC, IHC-P
Clone
10-1-62
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.7 mg/ml

Order Details

Caspase-7 Antibody (10-1-62) Summary

Immunogen
Recombinant human Caspase-7 protein (full length)
Specificity
Caspase-7 (10-1-62)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CASP7
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

May react with Hamster. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
In PBS, pH 7.2, 50mM sodium chloride, and 0.1mM PMSF.
Preservative
10mM Sodium Azide
Concentration
0.7 mg/ml
Purity
Protein G purified

Alternate Names for Caspase-7 Antibody (10-1-62)

  • apoptosis-related cysteine protease
  • Apoptotic protease Mch-3
  • CASP7
  • CASP-7
  • caspase 7, apoptosis-related cysteine peptidase
  • Caspase7
  • Caspase-7
  • EC 3.4.22
  • EC 3.4.22.60
  • ICE-like apoptotic protease 3
  • Lice2 alpha/beta/gamma
  • Mch3

Background

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Diseases for Caspase-7 Antibody (NBP1-19230)

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Blogs on Caspase-7.

Caspase 7 - A key effector of the apoptotic pathway
Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a...  Read full blog post.

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Bioinformatics

Gene Symbol CASP7
Entrez