Caspase-3 Products

Antibodies
Caspase-3 Antibody [Unconjuga ...
Caspase-3 Antibody [Unconjugated] ...
AF835
Species: Hu, Mu
Applications: IHC, ICC/IF
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
Caspase-3 Antibody - (active/ ...
Caspase-3 Antibody - (active/cleaved)
NB100-56113
Species: Hu, Mu, Rt, Ma
Applications: WB, Flow, Flow-IC, IB, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
ELISA Kits
Human Active Caspase-3 Quanti ...
Human Active Caspase-3 Quantikine ...
KM300
Species: Hu
Applications: ELISA
Human/Mouse Cleaved Caspase-3 ...
Human/Mouse Cleaved Caspase-3 (Asp...
DYC835-2
Species: Hu, Mu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Rat Caspase-3 ELISA Kit (Colo ...
Rat Caspase-3 ELISA Kit (Colorimet...
NBP2-75024
Species: Rt
Applications: ELISA
Kits
Caspase-3 Activity Assay Kit ...
Caspase-3 Activity Assay Kit (Colo...
NBP2-54838
Species: Hu, Mu, Rt, Ma
Applications: NULL
Caspase-3 Assay Kit (Fluorome ...
Caspase-3 Assay Kit (Fluorometric)
NBP2-54835
Species: Hu, Mu, Rt, Ma
Lysates
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate
NBL1-08710
Species: Hu
Applications: WB
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate
NBL1-08711
Species: Hu
Applications: WB
Proteins
Recombinant Human Pro-Caspase ...
Recombinant Human Pro-Caspase-3 Pr...
731-C3
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Caspase-3 Recombinant Protein ...
Caspase-3 Recombinant Protein Antigen
NBP1-90125PEP
Species: Hu
Applications: AC

Description

CPP32 encodes a member of the cysteine-aspartic acid protease (caspase) family that plays a key role in apoptosis. Caspase 3 (also known as CPP32, Apopain, Yama, and PARP cleavage protease) is the most extensively studied apoptotic protein among caspase family members (1-2). Caspase 3 is synthesized as an inactive proenzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). Alternative splicing of CPP32 results in two transcript variants which encode the same protein. The processed form of Caspase 3 consists of large (theoretical molecular weight 17kD) and small (theoretical molecular weight 12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28/Ser29 and Asp175/Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Variations in levels of Caspase 3 have been reported in cells of short-lived nature and those with a longer life cycle. Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease (3).

References

1.Mu, N., Lei, Y., Wang, Y., Wang, Y., Duan, Q., Ma, G.,... Su, L. (2019). Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Apoptosis, 24(9-10), 798-811. doi:10.1007/s10495-019-01559-3

2.Sun, C. M., Enkhjargal, B., Reis, C., Zhou, K. R., Xie, Z. Y., Wu, L. Y.,... Zhang, J. H. (2019). Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther, 25(10), 1162-1172. doi:10.1111/cns.13199

3.Louneva, N., Cohen, J. W., Han, L. Y., Talbot, K., Wilson, R. S., Bennett, D. A.,... Arnold, S. E. (2008). Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol, 173(5), 1488-1495. doi:10.2353/ajpath.2008.080434

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 836
Alternate Names
  • EC 3.4.22
  • CPP-32
  • Apopain
  • CASP-3
  • procaspase3
  • Protein Yama
  • PARP cleavage protease
  • Cysteine protease CPP32
  • caspase-3
  • apoptosis-related cysteine protease
  • Yama
  • EC 3.4.22.56
  • CPP32B
  • CPP32SREBP cleavage activity 1
  • SCA-1
  • caspase 3, apoptosis-related cysteine peptidase

Research Areas for Caspase-3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases
Phospho-Specific

Bioinformatics Tool for Caspase-3

Discover related pathways, diseases and genes to Caspase-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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D4-GDI (GDP dissociation inhibitor, RhoGD12)
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