Caspase-3 Products

Antibodies
Caspase-3 Antibody - Active
Caspase-3 Antibody - Active
AF835
Species: Hu, Mu
Applications: ICC
Host: Rabbit Polyclonal
Caspase-3 Antibody (1112I) [U ...
Caspase-3 Antibody (1112I) [Unconj...
MAB7071
Species: Hu
Applications: ICC
Host: Rabbit Monoclonal
Antibody Pairs
Caspase-3 Antibody Pair
Caspase-3 Antibody Pair
H00000836-AP11
Species: Hu
Applications: S-ELISA
Caspase-3 Antibody Pair
Caspase-3 Antibody Pair
H00000836-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
Caspase-3 ELISA Kit [HRP]
Caspase-3 ELISA Kit [HRP]
KA2637
Species: Hu, Mu, Rt
Applications: WB, ELISA
Kits
Caspase-3 Fluorometric Assay ...
Caspase-3 Fluorometric Assay Kit
KA0741
Species: Hu, Mu, Rt, Ma
Applications: Func
Caspase-3 Assay Kit
Caspase-3 Assay Kit
KA0744
Species: Hu, Mu, Rt, Ma
Applications: Flow, Func
Caspase-3 Assay Kit
Caspase-3 Assay Kit
KA0740
Species: Hu, Mu, Rt, Ma
Applications: Func
Lysates
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (N...
NBL1-08710
Applications: WB
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (N...
NBL1-08711
Applications: WB
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (D...
H00000836-T01
Applications: WB
Proteins
Caspase-3 Recombinant Protein ...
Caspase-3 Recombinant Protein
H00000836-P02
Species: Hu
Applications: WB, ELISA, PA
Caspase-3 Partial Recombinant ...
Caspase-3 Partial Recombinant Protein
H00000836-Q02
Species: Hu
Applications: WB, ELISA, PA
Caspase-3 Recombinant Protein ...
Caspase-3 Recombinant Protein
H00000836-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Caspase-3 RNAi
Caspase-3 RNAi
H00000836-R01
Species: Hu
Caspase-3 RNAi
Caspase-3 RNAi
H00000836-R02
Species: Hu

Description

Caspase 3 (CASP3) is a member of the cysteine-aspartic acid protease (caspase) family that is involved in the execution-phase of cell apoptosis.

There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Caspase 3 is considered an effector, as it is activated in the apoptotic cell both by extrinsic (death ligand) and intrinsic (mitochondrial) pathways. Specifically, procaspase is activated when the procaspase is cleaved at a particular residue. Activated Caspase 3 then cleaves numerous substrates to effect the morphological changes associated with apoptosis.

Caspase 3 antibodies are important tools for apoptosis studies and research on the caspase family mediated apoptosis signaling pathway.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 836
Alternate Names
  • EC 3.4.22
  • CPP-32
  • Apopain
  • CASP-3
  • procaspase3
  • Protein Yama
  • PARP cleavage protease
  • Cysteine protease CPP32
  • caspase-3
  • apoptosis-related cysteine protease
  • Yama
  • EC 3.4.22.56
  • CPP32B
  • CPP32SREBP cleavage activity 1
  • SCA-1
  • caspase 3, apoptosis-related cysteine peptidase

Research Areas for Caspase-3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases
Phospho-Specific

Bioinformatics Tool for Caspase-3

Discover related pathways, diseases and genes to Caspase-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Caspase-3 Blog Posts

Check out the latest blog posts on Caspase-3.
Caspase-3- A marker of programmed cell death
Caspases, or cysteine-dependent aspartate specific proteases, are a family of enzymes crucial for initiating and executing apoptosis within a cell, an important biological event especially during organ development (1). Environmental cues and cellul...    Read more.
Caspase 3, the executioner of apoptosis
Caspase-3 enzyme is a member of the family of endoproteases which regulate inflammation and apoptosis signaling networks. Caspase-3 is known as an executioner caspase in apoptosis because of its role in coordinating the destruction of cellular stru...    Read more.
Caspase 7 - A key effector of the apoptotic pathway
Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a...    Read more.
Caspase 11 - A proinflammatory caspase that induces the innate immune response
While known for their role in programmed cell death, caspases are also essential for mediating inflammatory responses and innate immunity. Binding of microbial molecules by pattern recognition receptors triggers the formation of the multiprotein in...    Read more.
LC3/LC3B - measuring autophagosome formation and autophagic flux
Microtubule-associated protein-1 light chain 3 (LC3/LC3B) is a ubiquitin-like protein involved in the formation of the autophagosome. It is homologous to the yeast Atg8 protein. Autophagosomes are important for the degradation and recycling of intr...    Read more.
D4-GDI (GDP dissociation inhibitor, RhoGD12)
The D4-GDI protein is a negative regulator of the Ras-related Rho family of small molecule "molecular switch" GTPases. The Rho GTPases modify cell structure and architecture via rapid changes to the actin cytoskeleton and cell membrane. M...    Read more.
LC3B - a novel marker for autophagosome
Autophagy, also known as macroautophagy, supplies alternative fuel for cells that are under environmental stress conditions (including starvation, growth factor deprivation, and hypoxia). This highly regulated and catabolic cell process recycles a...    Read more.
Read more Caspase-3 related blogs.