Caspase-3 Products

Description

CPP32 encodes a member of the cysteine-aspartic acid protease (caspase) family that plays a key role in apoptosis. Caspase 3 (also known as CPP32, Apopain, Yama, and PARP cleavage protease) is the most extensively studied apoptotic protein among caspase family members (1-2). Caspase 3 is synthesized as an inactive proenzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). Alternative splicing of CPP32 results in two transcript variants which encode the same protein. The processed form of Caspase 3 consists of large (theoretical molecular weight 17kD) and small (theoretical molecular weight 12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28/Ser29 and Asp175/Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Variations in levels of Caspase 3 have been reported in cells of short-lived nature and those with a longer life cycle. Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease (3).

References

1.Mu, N., Lei, Y., Wang, Y., Wang, Y., Duan, Q., Ma, G.,... Su, L. (2019). Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Apoptosis, 24(9-10), 798-811. doi:10.1007/s10495-019-01559-3

2.Sun, C. M., Enkhjargal, B., Reis, C., Zhou, K. R., Xie, Z. Y., Wu, L. Y.,... Zhang, J. H. (2019). Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther, 25(10), 1162-1172. doi:10.1111/cns.13199

3.Louneva, N., Cohen, J. W., Han, L. Y., Talbot, K., Wilson, R. S., Bennett, D. A.,... Arnold, S. E. (2008). Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol, 173(5), 1488-1495. doi:10.2353/ajpath.2008.080434

Bioinformatics

Entrez	836 Human 12367 Mouse 25402 Rat
Uniprot	P42574 Human P42574 Human NM_032991 Human NM_004346 Human AAH16926 Human AAH16926.1 Human NP_004337 Human NP_004337 Human
Product By Gene ID	836
Alternate Names	EC 3.4.22 CPP-32 Apopain CASP-3 procaspase3 Protein Yama PARP cleavage protease Cysteine protease CPP32 caspase-3 apoptosis-related cysteine protease Yama EC 3.4.22.56 CPP32B CPP32SREBP cleavage activity 1 SCA-1 caspase 3, apoptosis-related cysteine peptidase

Diseases related to Caspase-3

Discover more about diseases related to Caspase-3.

Malignant Neoplasms
Neoplasms
Leukemia
Carcinoma
Ischemia
Inflammation
Nerve Degeneration
Neuroblastoma
Liver Carcinoma
Alzheimer's Disease
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Brain Injuries
Hypoxia
Mammary Neoplasms
Reperfusion Injury
Adenocarcinoma
Lymphoma
Neurotoxicity Syndromes

Pathways for Caspase-3

View related products by pathway and learn more about each of the pathways below.

Cell Death
Induction Of Apoptosis
Cell Cycle
Cell Proliferation
Programmed Cell Death
Cell Growth
Pathogenesis
Apoptotic Process
Proteolysis
Cell Cycle Arrest
Localization
Neuroprotection
Release Of Cytochrome C From Mitochondria
Secretion
Dna Repair
Angiogenesis
Sensitization
Transport
Aging
Necrotic Cell Death

Research Areas for Caspase-3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases
Phospho-Specific

PTMs for Caspase-3

Learn more about PTMs related to Caspase-3.

Cleavage
Phosphorylation
Dephosphorylation
Reduction
Oxidation
Acetylation
Ubiquitination
Methylation
Nitrosylation
Biotinylation
Nitration
Glycosylation
Phosphorothioation
Ribosylation
Prenylation
Myristoylation
Demethylation
Amidation
Deacetylation
Sumoylation

Bioinformatics Tool for Caspase-3

Discover related pathways, diseases and genes to Caspase-3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related Caspase-3 Blog Posts

Check out the latest blog posts on Caspase-3.

Gut-brain axis: microbiota influence behavior and mental well-being By Jennifer Sokolowski, MD, PhD.Gut-microbiome interactionsOn and in our bodies, microbes outnumber our cells by about ten-to-one. Studies have revealed that the microbiome influences neurogenesis, cognition, and...    Read more.

The Ins and Outs of Survivin By Rachel M.A. Linger, Ph.D.What is survivin?Survivin is a small (16.5 kDa) protein normally found in human fetal tissue. In contrast, survivin is typically undetectable in most normal adult tissues. Expression of...    Read more.

Caspase-3- A marker of programmed cell death Caspases, or cysteine-dependent aspartate specific proteases, are a family of enzymes crucial for initiating and executing apoptosis within a cell, an important biological event especially during organ development (1). Environmental cues and cellul...    Read more.

Caspase 3, the executioner of apoptosis Caspase-3 enzyme is a member of the family of endoproteases which regulate inflammation and apoptosis signaling networks. Caspase-3 is known as an executioner caspase in apoptosis because of its role in coordinating the destruction of cellular stru...    Read more.

Caspase 7 - A key effector of the apoptotic pathway Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a...    Read more.

Caspase 11 - A proinflammatory caspase that induces the innate immune response While known for their role in programmed cell death, caspases are also essential for mediating inflammatory responses and innate immunity. Binding of microbial molecules by pattern recognition receptors triggers the formation of the multiprotein in...    Read more.

LC3/LC3B - measuring autophagosome formation and autophagic flux Microtubule-associated protein-1 light chain 3 (LC3/LC3B) is a ubiquitin-like protein involved in the formation of the autophagosome. It is homologous to the yeast Atg8 protein. Autophagosomes are important for the degradation and recycling of intr...    Read more.

D4-GDI (GDP dissociation inhibitor, RhoGD12) The D4-GDI protein is a negative regulator of the Ras-related Rho family of small molecule "molecular switch" GTPases. The Rho GTPases modify cell structure and architecture via rapid changes to the actin cytoskeleton and cell membrane. M...    Read more.

LC3B - a novel marker for autophagosome Autophagy, also known as macroautophagy, supplies alternative fuel for cells that are under environmental stress conditions (including starvation, growth factor deprivation, and hypoxia). This highly regulated and catabolic cell process recycles a...    Read more.

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