Caspase 3 Products

Antibodies
Caspase-3 Antibody - Active
Caspase-3 Antibody - Active
AF835
Species: Hu, Mu
Applications: ICC
Host: Rabbit Polyclonal
Caspase-3 Antibody (269518) [ ...
Caspase-3 Antibody (269518) [Uncon...
MAB835
Species: Hu, Mu
Applications: WB, ICC
Host: Rabbit Monoclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
Caspase-3 Antibody Pair
Caspase-3 Antibody Pair
H00000836-AP11
Species: Hu
Applications: S-ELISA
Caspase-3 Antibody Pair
Caspase-3 Antibody Pair
H00000836-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
Human, Mouse, Rat Caspase-3 E ...
Human, Mouse, Rat Caspase-3 ELISA Kit
KA2637
Species: Hu, Mu, Rt
Applications: WB, ELISA
Kits
Caspase-3 Colorimetric Assay ...
Caspase-3 Colorimetric Assay Kit
NBP2-54838
Species: Hu, Mu, Rt, Ma
Caspase-3 Colorimetric Assay ...
Caspase-3 Colorimetric Assay Kit
KA0740
Species: Ma
Applications: Func
Caspase-3 Fluorometric Assay ...
Caspase-3 Fluorometric Assay Kit
NBP2-54835
Species: Hu, Mu, Rt, Ma
Lysates
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (N...
NBL1-08711
Applications: WB
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (N...
NBL1-08710
Applications: WB
Caspase-3 Overexpression Lysa ...
Caspase-3 Overexpression Lysate (D...
H00000836-T01
Species: Hu
Applications: WB
Proteins
Recombinant Caspase-3 Protein ...
Recombinant Caspase-3 Protein
NB731-C3-005
Recombinant Human Caspase-3 P ...
Recombinant Human Caspase-3 Protein
H00000836-P02
Species: Hu
Applications: WB, ELISA, PA
Caspase-3 Recombinant Protein ...
Caspase-3 Recombinant Protein Antigen
NBP1-90125PEP
Species: Hu
Applications: AC
RNAi
Caspase-3 RNAi
Caspase-3 RNAi
H00000836-R02
Species: Hu
Applications: RNAi, RNAi SP
Caspase-3 RNAi
Caspase-3 RNAi
H00000836-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Caspase 2 is a member of the cysteine-aspartic acid protease (caspase) family and acts as both a positive and negative regulator of apoptosis. Over expression of the full length Caspase 2 (Isoform ICH-1L) in some cell types results in apoptosis whereas the over expression of an alternative Caspase 2 (ICH-1S) splice variant suppresses apoptosis.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 835
Alternate Names
  • caspase-2
  • CASP-2
  • ICH-1S
  • Protease ICH-1
  • ICH-1L
  • Neural precursor cell expressed developmentally down-regulated protein 2
  • NEDD2neural precursor cell expressed, developmentally down-regulated 2
  • ICH1EC 3.4.22.55
  • NEDD-2
  • caspase 2, apoptosis-related cysteine peptidase

Research Areas for Caspase 3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Caspases

PTMs for Caspase 3

Learn more about PTMs related to Caspase 3.

Cleavage
Phosphorylation
Biotinylation
Ubiquitination
Reduction
Isgylation

Bioinformatics Tool for Caspase 3

Discover related pathways, diseases and genes to Caspase 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Caspase 3 Blog Posts

Check out the latest blog posts on Caspase 3.
Apoptosis and Necroptosis Part I: Important factors to identify both types of programmed cell death
Different types of cell death have classically been identified by discrete morphological changes. The hallmarks of apoptosis include cell shrinkage, nuclear fragmentation and membrane blebbing whereas necroptosis is characterized by cell swelling...    Read more.
Pathway Highlight: Three key factors that contribute to cellular heterogeneity in apoptosis
Have you ever wondered why cells in the same population respond differently to an apoptotic stimulus? Apoptosis, a form of programmed cell death, is vital for the removal of unwanted or damaged cells. As with most cellular processes, too much or to...    Read more.
The role of Parkin and autophagy in retinal pigment epithelial cell (RPE) degradation
The root of Parkinson’s disease (PD) points to a poorly regulated electron transport chain leading to mitochondrial damage, where many proteins need to work cohesively to ensure proper function.  The two key players of this pathway are PINK1,...    Read more.
The dynamic use of a PCNA antibody in fish, porcine and primate species
Proliferating cell nuclear antigen (PCNA) plays a crucial role in nucleic acid metabolism as it pertains to DNA replication and repair.  Most noted for its activation of subunits of DNA polymerase, it has also been found to interact with cell-cycl...    Read more.
The use of a GFP antibody for research applications in transgenic C. elegans, GFP tagged yeast and porcine model
GFP, or green fluorescent protein, is a chemiluminescent protein derived from Aequorea jellyfish that was first discovered by Osamu Shimomura.  It was soon after established that the emission spectra of GFP was right around 509nm, or the ultraviol...    Read more.
Required proteins for p62/SQSTM1 regulation and a role for p62/SQSTM1 in neuronal autophagy
Autophagy is a crucial cellular process that clears the cell of protein aggregates, toxins, and damaged cell products. Accumulation of toxins, damaged cell products and unwanted proteins has been proven to play a role in aging and many forms of dis...    Read more.
The role of LC3B and autophagy in alcohol induced liver disease
Autophagy is a crucial intracellular pathway that manages the degradation and recycling of long-lived proteins in the cell. The LC3 (or light chain 3) family is composed of three members, LC3A, LC3B and LC3C. Upon autophagy induction, LC3 is cleave...    Read more.
Caspase 3 - a Reliable Marker for Index of Apoptosis Induction
Caspase-3 is one of the most important players in apoptosis signaling. It is synthesized as an inactive 32 kDa pro-enzyme and upon direct activation by Caspase-8, -9 or -10, it gets processed into its active forms, the p17-20 and p10-12 subunits. T...    Read more.
Survivin - an inhibitor of apoptosis protein
Survivin is an anti-apoptotic protein which is the smallest protein within a large family of proteins including X-linked IAP, c-IAP1 and 2, IAP-like protein-2, melanoma IAP, NAIP, and Livin. Survivin is responsible for a wide range of basic cellula...    Read more.
Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...    Read more.
Apoptosis Happens
Cell death via apoptosis is a basic cellular function occurring through the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Caspases have a precursor form composed of a pr...    Read more.
Caspase 9 and Mitochondrial Apoptosis Regulation
Caspase 9 (also termed ICE-LAP6, Mch6, Apaf-3) is a member of cysteine protease family of caspases and is encoded by the CASP9 gene in humans. Caspase-9 is involved in mitochondrial apoptosis pathway and is an initiator caspase. Pro-caspase-9 is activ...    Read more.
Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all...    Read more.
Caspase 3/7 Inhibitors Show Potential for Anti-Inflammatory Therapies
Apoptosis is one of the best-characterized phenomena in cellular and molecular biology. Not only is it essential for successful development, but its deregulation also leads to a number of human diseases, most notably cancer. The cysteine aspartate pro...    Read more.
S100A6: Playing Roles in Cancer, Apoptosis & Transcription Regulation
S100A6 antibodies detect a small calcium binding protein with 2 EF-hand structures and belongs to the S100 family. Calcium binding induces a conformational change of the protein which in turn permits its interaction with several target proteins. It is...    Read more.
Heat Shock Proteins: An Overview
Heat Shock Proteins (HSPs) are a ubiquitous group of molecular chaperone proteins that have evolved unique mechanisms, within their host cells, to facilitate survival in hostile environments such as heat, oxidative (hypoxia), pH and cold. Under permis...    Read more.
The Role of the Caspase 3 Antibody in Apoptosis Research
The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.Human caspases form three distinct groups: cytokine activators, which are...    Read more.
PARP Antibody Assays aid both Apoptosis and Cancer Research
The PARP (Poly(ADP-ribose) polymerase) protein is a zinc-dependant nuclear enzyme whose main role is to detect and repair DNA single-strand breaks (SSB). However, PARP antibody research has revealed there are at least 17 PARP proteins, which also play...    Read more.
Caspase Antibody Study Shows Link to Heart Disease
Caspase 3 is a member of the cysteine-aspartic acid protease family and an important mediator of apoptosis. Caspase 3 antibody reagents have been used in cancer, Alzheimer's disease and stem cell research. A recent caspase 3 antibody ELISA study showe...    Read more.
Read more Caspase 3 related blogs.