CARD11/CARMA1 Antibody

Images

 
Western Blot: CARD11/CARMA1 Antibody [NBP1-77219] - Western blot analysis of CARD11 expression in mouse thymus cell lysate with anti-CARMA1 using antibody at 0.5 (lane A), 1 (lane B), and 2 ug /ml (lane C), respectively.
Immunocytochemistry/ Immunofluorescence: CARD11/CARMA1 Antibody [NBP1-77219] - Immunofluorescence of CARMA1 in Mouse Spleen cells with CARMA1 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: CARD11/CARMA1 Antibody [NBP1-77219] - Mouse thymus with CARD11 antibody at 10 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

CARD11/CARMA1 Antibody Summary

Immunogen
Antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1. The immunogen is located within the last 50 amino acids of CARMA1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CARD11
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
Application Notes
This antibody can be used for detection of CARMA1 by Western blot at 0.5 to 2 mg/ml. A band at approximately 125 kDa can be detected.
Control Peptide
CARD11/CARMA1 Peptide (NBP1-77219PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CARD11/CARMA1 Antibody

  • BIMP3
  • BIMP3card-maguk protein 1
  • CARD11
  • CARD-containing MAGUK protein 1
  • Carma 1
  • CARMA1
  • CARMA1bcl10-interacting maguk protein 3
  • caspase recruitment domain family, member 11
  • caspase recruitment domain-containing protein 11
  • MGC133069

Background

CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkappaK complex, thereby regulating activation of the NF-kappaB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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ICC/IF Video Protocol

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Bioinformatics

Gene Symbol CARD11
Entrez
Uniprot