Carboxylesterase 3/CES3/Esterase 31 Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Mu, Rt
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 594

Carboxylesterase 3/CES3/Esterase 31 Antibody [Alexa Fluor™ Plus 594] Summary

• Specificity: Detects recombinant mouse Carboxylesterase 3/CES3 in direct ELISAs and Western blots. Detects intrinsic CES3 in mouse and rat tissues in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) CES1, rhCES2, recombinant mouse (rm) CES2, and rmCES5 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Carboxylesterase 3/CES3/Esterase 31 Antibody [Alexa Fluor™ Plus 594]

• carboxylesterase 3 (brain)
• Carboxylesterase 3
• CES3
• EC 3.1.1
• EC 3.1.1.1
• ES31FLJ21736
• esterase 31
• Liver carboxylesterase 31 homolog

Background

Carboxylesterase 3 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). These carboxylesterases are widely distributed in mammalian tissues and have broad substrate specificity ranging from small molecule esters such as phenylester to long-chain fatty acid esters and thioesters. Because many ester-containing drugs require the ester linkage to improve the bioavailability of therapeutic agents, CESs play a major role in drug metabolism and activation. CES3 is also known as triacylglycerol hydrolase for its lipolytic activity. It has been reported to be the major lipase in white adipose tissue (3). Mouse CES3 shares 93% homology with rat CES3.

1. Redinbo, M. R. and Potter, P.M. (2005) Drug Discovery Today. 10:313.
2. Satoh, T. and Hosokawa, M. (2006) Chem.-Biol. Interactions. 162:195.
3. Soni, K. G. et al. (2004) J. Biol. Chem. 279:40683.

 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.